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Poison Pills: The Untold Story of the Vioxx Drug Scandal


by Tom Nesi

List Price: $25.95
Price: $17.13
You Save: $8.82 (34%)
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Sales Rank: 84113
Studio: Thomas Dunne Books
Binding: Hardcover
Number Of Pages: 320
Publication Date: September 16, 2008
Publisher: Thomas Dunne Books


EDITORIAL REVIEWS

Product Description

To the millions of Americans who suffer from chronic pain and arthritis, Vioxx seemed like a miracle. One of the most widely promoted and prescribed pain medications in the world -- used by more than twenty million people -- it was endorsed by the medical establishment and celebrities such as Olympic champion figure skater Dorothy Hamill. With annual sales of $2.5 billion, Vioxx became a pharmaceutical bonanza before being abruptly taken off the market in September 2004, after it was revealed that it led to an increased risk of heart-related disease and death.

Drawing on internal documents, video footage, court testimony, and exclusive interviews, as well as three decades of experience inside the medical industry, Tom Nesi tells the dramatic story of what the drug’s manufacturer, Merck, knew and when. It is a compelling narrative of business and medical science run amok, with a cast of characters ranging from those at the highest levels of the multibillion-dollar pharmaceutical industry to research scientists, marketers, and drug company sales reps. Here also are accounts from physicians, lawyers, financial analysts, and patients and their families whose lives have been forever altered by Vioxx.

Set against a fascinating history of the origins of the modern pharmaceutical industry, POISON PILLS is a shocking tale that involves the breakdown of the United States medical system, the failures of the Food and Drug Administration, and enormous profits made by a large pharmaceutical corporation at the potential cost of thousands of lives.



CUSTOMER REVIEWS (Average Customer Rating: 3.0 based on 7 reviews)

A movie script for a tragic story in drug development  
The book Poison Pills reads like a a movie script. The author captures the inside story of the development of a drug as if he were a fly in the wall during the deliberations that led to some of the key decisions in the tragic story of Vioxx. The anecdotes and vignettes are sometimes amusing. The exaggerated caricature depictions of some of the players should provide some object lessons for those still engaged in the noble cause of bringing new and innovative pharmaceuticals into the world. Poison Pills reads like fiction but I wish it were so.
September 28, 2008

A terrific read!  
A riveting story, expertly told with lively narrative skill and dashes of humor as well as thorough documentation, "Poison Pills" is a vitally important book that casts new light on important issues surrounding health and medicine. The Vioxx scandal was a shocking abuse of power by one of the world's largest and most prestigious pharmaceutical companies--and the author makes it clear that the problems are not necessarily confined to Merck but may be a symptom of the pressures faced by all medical manufacturers. This book really makes you think and it's also highly entertaining, showing the human side of the story with a full range of emotions. Highly recommended to everyone!
September 24, 2008

Vioxx 101 for the Plaintiff  
"Poison Pills" is not the book I thought it would be! It's nothing like
the "standard" pharmaceutical exposes. You can tell it really tells the
story from the inside. It sure isn't dry or dull. This is stuff you haven't
read before and it goes way beyond the story of Vioxx. Even if you've never
heard of the drug, you'll be fascinated by the behind the scenes corporate
and medical deals. One last thing. It is funny! Many stories are
entertaining. They are so outrageous, they must be true. No one is spared.
Caution: you might never take an aspirin after this!

September 19, 2008

Astonishing untruthful bias - rubbish  
This is sensationalist claptrap. The book was written by someone who was paid by plaintiff attorneys to serve as a witness on their behalf in the Vioxx lawsuits, so is inherently biased.

A balanced view of the issues would, admittedly, not make for such an exciting story but the facts have been grossly distorted here, so it is not informative.

Evidence in scientific research varies in rigor - and as soon as Merck had good quality evidence pointing to an increased risk (albeit a very small increased risk - which most people would be prepared to take for the benefit that the drug provided them) they pulled the drug, voluntarily.
September 19, 2008

Biased and irresponsible  
This book deserves much discredit. First, the author was a paid consultant by the lawsuit plaintiffs, so he is not objective. Second, he worked at Bristol-Myers Squibb and would have an ax to grind with Merck. Third, he ignores the continued evidence that Merck continually acted in the best interest of patients. The drug was carefully studied before and after approval and consistently made all results available to FDA and medical community. Merck acted within one week after its own studies initially suggested an increased risk after 18 months of continuous use. Note that standard chronic tox studies (approved by FDA) are conducted for 12 months. The information available at 18 months was not known prior to approval, but once known was acted upon swiftly with a voluntary withdrawal.

It is time to get past emotions and return to facts. This book does not.
Just because something is in print does not make it so.
September 19, 2008


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