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Oxidative Stress and Neurodegenerative Disorders


by G. Ali Qureshi, S. Hasan Parvez

List Price: $170.00
Available: Usually ships in 24 hours
Sales Rank: 1785420
Studio: Elsevier Science
Binding: Hardcover
Number Of Pages: 794
Publication Date: May 03, 2007
Publisher: Elsevier Science


EDITORIAL REVIEWS

Product Description
Oxidative stress is the result of an imbalance in pro-oxidant/antioxidant homeostasis that leads to the generation of toxic reactive oxygen species. Brain cells are continuously exposed to reactive oxygen species generated by oxidative metabolism, and in certain pathological conditions defense mechanisms against oxygen radicals may be weakened and/or overwhelmed. DNA is a potential target for oxidative damage, and genomic damage can contribute to neuropathogenesis. It is important therefore to identify tools for the quantitative analysis of DNA damage in models on neurological disorders. This book presents detailed information on various neurodegenerative disorders and their connection with oxidative stress. This information will provide clinicians with directions to treat these disorders with appropriate therapy and is also of vital importance for the drug industries for the design of new drugs for treatment of degenerative disorders.

* Contains the latest information on the subject of neurodegenerative disorders
* Reflects on various factors involved in degeneration and gives suggestions for how to tackle these problems


CUSTOMER REVIEWS (Average Customer Rating: 5.0 based on 1 review)

Excellent Book  
This book is a pleasant surprise, very well organized and written. I am not an MD, but an organic chemist and possible movement disorder patient. This book is unique in that it is written for a multitude of different people; scientists, medical doctors, researchers, patients, etc. The book is not written above anyone's head but rather in a nice, easy style where they get straight to the point. One of the best parts of this book is they cover strategies for reversing or eliminating oxidative stress. There is a chapter on green/black tea as well as much information about potent antioxidants. They also cover the unique properties of melatonin as a neuroprotective agent and I learned that even estrogen has potent neuroprotective effects. My only complaint is that they frequently mention certain chemicals without ever showing their structure, many books make this mistake nowadays. Get a Merck Index to go along with this book and you can look up the structures they don't show. Other gems in this book are chapters on dietary strategies to combat oxidative stress and the prevention and treatment of neurodegenerative disorders. These guys actually cover nutrition and its very powerful effect on neurodegeneration or its prevention. This text has something for every scientist or patient and I firmly believe it is worth every penny it costs, even more. One minor, but unexceptable mistake, is they show the incorrect structure of melatonin on page 741; they left the 5-methoxy group off! Here are two examples of the type of excellent info presented:

"The ability of tea polyphenols to act as reletively potent metal chelators may be of significance for the treatment of neurodegenerative disease, in which accumulation of iron has been found in areas of the brain where neurodegeneration occurs."

"Moreover, it was shown that green and black tea exhibited neuroprotective effects on Parkinsonism inducing neurotoxin 6-OHDA which initiated...cell death in culture because 6-OHDA is readily autooxidized and oxidatively deaminated by MAO, to give rise to reactive oxygen species."

For such a recent and authoritative text to cover nutrition as well as this one does is remarkable. The editors of this excellent book have done great work which will be of tremendous help to a multitude of people interested in "brain health." You do not have to be a scientist to benefit from this book, although some science background is necessary. Nutritionists will also benefit from reading and owning this book. If you are interested in neurochemistry and the preservation of your mental capacities, this is a must have book. If you treat or live with a patient who suffers from neurodegeneration, you will be glad to have access to this information which will help you decide how to approach or develop a POA (plan of action).
November 25, 2007
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