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Drug Resistance in Cancer: Mechanisms and Models


by James H. Goldie, Andrew J. Coldman

List Price: $145.00
Available: Usually ships in 2 to 3 weeks
Sales Rank: 893417
Studio: Cambridge University Press
Binding: Hardcover
Number Of Pages: 247
Publication Date: November 13, 1998
Publisher: Cambridge University Press


EDITORIAL REVIEWS

Product Description
Drug resistance in cancer, whereby a portion of cancer cells evades chemotherapy, poses a profound and continuing challenge for the effective treatment of cancer. The principles underlying the biological mechanisms behind this phenomenon are clearly explained in this volume. A deeper understanding of drug resistance requires a quantitative appreciation of the dynamic forces that shape tumor growth, including spontaneous mutation and selection processes. The authors seek to explain and to simplify these complex mechanisms, and to place them in a clinical context. Clearly explained mathematical models are used to illustrate the biological principles and provide an insight into tumor development and the effectiveness and limitations of drug treatment. The volume is suitable for those with a nonmathematical background and aims to enhance the effectiveness of cancer therapy. This is the first book to provide such an integrated account, in a form accessible to both doctor and scientist.


CUSTOMER REVIEWS (Average Customer Rating: 5.0 based on 1 review)

A Primary Sourcebook for Chemotherapists  
This an extremely sophisticated analysis of one of the most troubling aspects of chemotherapy, namely the tendency over time for a patient to develop resistance to the agent being applied. The Goldie-Coldman model for resistance is one of the best known in chemotherapy. Since it operates at a level of some mathematical complexity, some physicians and biochemists have found it somewhat off-putting. However, in this book, the authors have carefully minimized mathematical complexity and emphasized an intuitive approach which is very approachable by most oncologists. This book is an excellent resource, one which should be in the library of every chemotherapist,
April 03, 2000
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