On Speed: The Many Lives of Amphetamine

"Rasmussen, who has taught life sciences and medicine at UCLA and other universities, examines amphetamine as a case study on the place drugs occupy in our culture and our fantasies (of miracle cures and elixirs). The story begins with chemist Gordon Alles’s creation of amphetamine in 1929 and continues through its use for weight loss, attention deficit disorders and today’s crystal meth craze. Smith, Kline & French (now GlaxoSmithKline) bought the rights for use of the drug and marketed it to treat depression. During WWII, British and American soldiers developed an amphetamine appetite as RAF medics distributed wakey-wakey tablets to bomber crews. At the book’s core is an outstanding chapter, Bootleggers, Beatniks and Benzedrine Benders, describing how Benzedrine inhalers, available without a prescription, could be cracked open for a totally new kind of amphetamine experience, exerting a potent influence on music and literature, from Charlie Parker to Jack Kerouac and Allen Ginsberg. Rasmussen has mined magazines, books and newspapers in addition to extensive explorations through U.K. and American archives. He concludes by calling for strong and immediate action to curb the widespread, dangerous use and abuse of amphetamines, emphasizing treatment and harm reduction (like needle exchange) rather than punishment, and better regulation of the pharmaceutical industry."

—Publishers Weekly

Uppers. Crank. Bennies. Dexies. Greenies. Black Beauties. Purple Hearts. Crystal. Ice. And, of course, Speed. Whatever their street names at the moment, amphetamines have been an insistent force in American life since they were marketed as the original antidepressants in the 1930s. On Speed tells the remarkable story of their rise, their fall, and their surprising resurgence. Along the way, it discusses the influence of pharmaceutical marketing on medicine, the evolving scientific understanding of how the human brain works, the role of drugs in maintaining the social order, and the centrality of pills in American life. Above all, however, this is a highly readable biography of a very popular drug. And it is a riveting story.

Incorporating extensive new research, On Speed describes the ups and downs (fittingly, there are mostly ups) in the history of amphetamines, and their remarkable pervasiveness. For example, at the same time that amphetamines were becoming part of the diet of many GIs in World War II, an amphetamine-abusing counterculture began to flourish among civilians. In the 1950s, psychiatrists and family doctors alike prescribed amphetamines for a wide variety of ailments, from mental disorders to obesity to emotional distress. By the late 1960s, speed had become a fixture in everyday life: up to ten percent of Americans were thought to be using amphetamines at least occasionally.

Although their use was regulated in the 1970s, it didn’t take long for amphetamines to make a major comeback, with the discovery of Attention Deficit Disorder and the role that one drug in the amphetamine family—Ritalin—could play in treating it. Todays most popular diet-assistance drugs differ little from the diet pills of years gone by, still speed at their core. And some of our most popular recreational drugs—including the "mellow" drug, Ecstasy—are also amphetamines. Whether we want to admit it or not, writes Rasmussen, were still a nation on speed.