Product Description
Outlines strategies for stimulating capillary formation in hypoxia and ischemia and inhibiting it in cancer, diabetes, and chronic inflammation. This state-of-the-science reference highlights recent progress in the ways to promote formation of new blood vessels in ischemic/hypoxic tissue and the means to stifle capillary growth and development in solid tumors, diabetic retinopathy, and chronic immuno/inflammatory disorders such as rheumatoid arthritis and psoriasis. Emphasizes practical clinical applications derived from the latest angiogenesis research. Written by over 80 leading international experts, Angiogenesis in Health and Disease · examines new angiogenic regulators such as angiopoietins and TIE-receptors · describes angiogenic genes such as thymosine B-4, EDG-1, and ARNT proteins · analyzes the role of vascular endothelial growth factor (VEGF) in capillary sprouting · investigates behaviors of endogenous agents of angiogenesis, including cytokines, hormones, chemokines, and peptide and hematopoietic growth factors · explores mechanisms for ameliorating or preventing vascular occlusive disease by induction of collateral artery growth · explains differences in conditions that prompt angiogenesis and arteriogenesis · reviews transgenic and knock-out mice, receptor protein mutations, and other emerging technologies · evaluates angiogenic inhibitors such as angiostatin and endostatin · and more! Containing over 3000 references, tables, drawings, and photographs, Angiogenesis in Health and Disease deserves a prominent place on the bookshelves of cardiologists, oncologists, physiologists, hematologists, molecular and cell biologists, biochemists, pharmacologists, rheumatologists, vascular surgeons, and upper-level undergraduate, graduate, and medical school students in these disciplines.