Brightsurf Science News and Current Science News Events
 

View Larger Image

Effects of the fungicide prochloraz on the sexual development of zebrafish (Danio rerio) [An article from: Comparative Biochemistry and Physiology, Part C]


by K. Kinnberg, H. Holbech, G.I. Petersen, Bjerregaar

List Price: $10.95
Available: Available for download now
Studio: Elsevier
Binding: Digital
Number Of Pages: 5
Publication Date: March 01, 2007
Publisher: Elsevier


FORMATS

  • HTML


EDITORIAL REVIEWS

Product Description
This digital document is a journal article from Comparative Biochemistry and Physiology, Part C, published by Elsevier in 2007. The article is delivered in HTML format and is available in your Amazon.com Media Library immediately after purchase. You can view it with any web browser.

Description:
Some chemicals have the potential to adversely affect sexual development through multiple endocrine actions. Prochloraz is an imidazole fungicide that displays diverse mechanisms of action, including inhibition of aromatase activity, inhibition of androgen synthesis, and antagonism of the androgen receptor. The objective of this study was to assess the effects of prochloraz on the sexual development of zebrafish (Danio rerio) in the Fish Sexual Development Test (FSDT) proposed as an OECD test guideline for detection of endocrine disruptors. Zebrafish were exposed to prochloraz (0, 16, 64 or 202 @mg/L) for 60 days from 24 h post fertilization. Fish exposed to 202 @mg/L prochloraz showed an increased proportion of males. Furthermore, the incidence of intersex and the stages of the gonads were altered in the treated fish compared to the control fish. A significant vitellogenin decrease was observed in both female and male zebrafish at an exposure concentration of 202 @mg/L prochloraz. However, in the male fish, significantly increased vitellogenin concentrations were observed in the groups exposed to 16 or 64 @mg/L prochloraz. This study serves as a part of the validation of the FSDT and indicates that the FSDT is suitable in detecting compounds with multiple endocrine actions. This is of importance in the assessment of the potential risk of existing and new chemicals.
© 2008 BrightSurf.com