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DNA damage-induced activation of ATM and ATM-dependent signaling pathways [An article from: DNA Repair]

by E.U. Kurz, S.P. Lees-Miller

List Price:

$14.95

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Available for download now

Studio:

Elsevier

Binding:

Digital

Publication Date:

July 24, 2008

Publisher:

Elsevier

FORMATS
HTML
EDITORIAL REVIEWS
Product Description This digital document is a journal article from DNA Repair, published by Elsevier in 2004. The article is delivered in HTML format and is available in your Amazon.com Media Library immediately after purchase. You can view it with any web browser. Description: Ataxia-telangiectasia mutated (ATM) plays a key role in regulating the cellular response to ionizing radiation. Activation of ATM results in phosphorylation of many downstream targets that modulate numerous damage response pathways, most notably cell cycle checkpoints. In this review, we describe recent developments in our understanding of the mechanism of activation of ATM and its downstream signaling pathways, and explore whether DNA double-strand breaks are the sole activators of ATM and ATM-dependent signaling pathways.