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| View Larger Image | The neuropsychology of ventral prefrontal cortex: Decision-making and reversal learning [An article from: Brain and Cognition]
by L. Clark, R. Cools, T.W. Robbins
| | List Price: | $5.95 |  | | Available: | Available for download now | | | | | Studio: | Elsevier | | | Binding: | Digital | | Publication Date: | June 01, 2004 | | Publisher: | Elsevier |
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Product Description
This digital document is a journal article from Brain and Cognition, published by Elsevier in 2004. The article is delivered in HTML format and is available in your Amazon.com Media Library immediately after purchase. You can view it with any web browser.
Description:
Converging evidence from human lesion, animal lesion, and human functional neuroimaging studies implicates overlapping neural circuitry in ventral prefrontal cortex in decision-making and reversal learning. The ascending 5-HT and dopamine neurotransmitter systems have a modulatory role in both processes. There is accumulating evidence that measures of decision-making and reversal learning may be useful as functional markers of ventral prefrontal cortex integrity in psychiatric and neurological disorders. Whilst existing measures of decision-making may have superior sensitivity, reversal learning may offer superior selectivity, particularly within prefrontal cortex. Effective decision-making on existing measures requires the ability to adapt behaviour on the basis of changes in emotional significance, and this may underlie the shared neural circuitry with reversal learning. |
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