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Product Description This digital document is a journal article from Analytica Chimica Acta, published by Elsevier in . The article is delivered in HTML format and is available in your Amazon.com Media Library immediately after purchase. You can view it with any web browser. Description: A novel and simple capillary zone electrophoresis method was developed and validated for the simultaneous determination of rosiglitazone and metformin in pharmaceutical preparations. The optimum separation for these analytes was achieved in <9min at 25^oC with a fused-silica capillary column (80.5cmx75@mm i.d., effective length 72.0cm) and a running buffer containing 25mM acetate buffer at pH 4.0. The samples were injected hydrodynamically for 3s at 50mbar and the applied voltage was +25.0kV. Detection wavelength was set at 203nm. Verapamil was used as internal standard. The method was suitably validated with respect to specificity, linearity, limit of detection and quantitation, accuracy, precision, and robustness. The limits of detection and quantitation were 0.5 and 1.0@mgmL^-^1 for rosiglitazone and metformin, respectively. The method developed was successfully applied to the simultaneous determination of rosiglitazone and metformin in pharmaceutical preparations. The results were compared to a liquid chromatographic method reported in the literature and no significant difference was found statistically.