FORMATS
HTML
EDITORIAL REVIEWS
Product Description This digital document is an article from The Psychological Record, published by Thomson Gale on June 22, 2007. The length of the article is 6326 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser. From the author: Schedule-induced polydipsia in rats was developed by means of a fixed-time 60-s schedule of food presentation. The acute administration of d-amphetamine sulfate (0.1-3.0 mg/kg) produced a dose-dependent decrease in the rate of licking. d-Amphetamine shifted to the left the temporal distribution of adjunctive drinking within interfood intervals. Dopaminergic antagonists SCH23390 ([R(+)-7-chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride], 0.001-0.01 mg/kg), eticlopride (0.001-0.03 mg/kg), and flupenthixol (0.03-0.3 mg/kg) also produced dose-dependent decreases in licks per minute but did not alter the temporal distribution of adjunctive behavior. Selective doses of dopaminergic antagonists further suppressed licking rates when combined with d-amphetamine, 1.0 mg/kg, but an antagonism could be observed on the temporal distribution after the administration of SCH23390 (0.01 mg/kg) or flupenthixol (0.1 mg/kg). The dopaminergic agonists SKF38393 ([R(+)-1-phenyl-7,8-dihydroxy-2,3,4,5-tetrahydro-1H-3-bezazepine hydrochloride]; 1.0-10.0 mg/kg) and quinpirole (0.003-0.03 mg/kg) produced a dose-dependent decrease in the rate of licking, and when combined with d-amphetamine, additive-like suppressive effects were found. These results suggest a dopaminergic selectivity for the effects of d-amphetamine on the temporal distribution of schedule-induced polydipsia. Citation Details Title: Dopaminergic actions of d-amphetamine on schedule-induced polydipsia in rats.(dextroamphetamine)(Report) Author: Ricardo Pellon Publication: The Psychological Record (Magazine/Journal) Date: June 22, 2007 Publisher: Thomson Gale Volume: 57 Issue: 3 Page: 339(19) Article Type: Report Distributed by Thomson Gale