| View Larger Image | The Regulatory Genome: Gene Regulatory Networks In Development And Evolution | Hardcoverby Eric H. Davidson (Author)
| List Price: | $79.95 | | Price: | $63.96 | | You Save: | $15.99 (20%) | | | Available: | Usually ships in 24 hours |
| | Binding: | Hardcover | | Publisher: | Academic Press | | Edition: | 1st Edition | | Page Count: | 304 Pages | | Publication Date: | June 13, 2006 | | Sales Rank: | 502,429nd |
|
EDITORIAL REVIEWS |
Product Description
Gene regulatory networks are the most complex, extensive control systems found in nature. The interaction between biology and evolution has been the subject of great interest in recent years. The author, Eric Davidson, has been instrumental in elucidating this relationship. He is a world renowned scientist and a major contributor to the field of developmental biology. The Regulatory Genome beautifully explains the control of animal development in terms of structure/function relations of inherited regulatory DNA sequence, and the emergent properties of the gene regulatory networks composed of these sequences. New insights into the mechanisms of body plan evolution are derived from considerations of the consequences of change in developmental gene regulatory networks. Examples of crucial evidence underscore each major concept. The clear writing style explains regulatory causality without requiring a sophisticated background in descriptive developmental biology. This unique text supersedes anything currently available in the market. * The only book in the market that is solely devoted to the genomic regulatory code for animal development * Written at a conceptual level, including many novel synthetic concepts that ultimately simplify understanding * Presents a comprehensive treatment of molecular control elements that determine the function of genes * Provides a comparative treatment of development, based on principles rather than description of developmental processes * Considers the evolutionary processes in terms of the structural properties of gene regulatory networks * Includes 42 full-color descriptive figures and diagrams |
CUSTOMER REVIEWS (Average Customer Rating: 3.5 based on 2 reviews)
|
advanced, difficult, important by OhioValley (Kentucky)  2 Stars
December 30, 2007
If you really want to understand what is known about DNA transcription, you will first get a 500 level background in cell biology and biochemistry. After reading Genomes 3 by TA Brown (very good) you will hav a 600 level understanding. Now at the 700 level, the reading is tougher and doesn't fit together very well. You will need to read "Epigenetics" by Allis et al, since other authors mostly ignore it and it is important. Next, learn some embryology, which should be in an appendix in Davidson, but isn't.
Now you are ready for Davidson's "The Regulatory Genome." It is difficult and poorly explained. The core material is in multi-page figures with multi-page captions. The combination of no legend for the diagramming conventions, and highly complex biology, will surprise you if you are used to readily-understood biology figures. The transcription regulation discussed is that of embryological development, which is rather different from the metabolic enzyme regulation discussed in cell biology and biochemistry. If you stop struggling with the details in the figures, and hold them at arm's length, you get a glimpse of the essence of developmental biology at the molecular level.
There is much that isn't covered -- heterochromatin, euchromatin, transcription differences between the sexes, the master timing mechanism, the role of noncoding DNA -- but this is the frontier. If you want that glimpse, you should learn the prerequesite material, and THEN read Davidson.
| |
A real theory of biology and evolution by P. Calvert (Potomac, MD USA)  5 Stars
March 22, 2007
This book will be a revelation to any biologist who has not been reading the literature on development and embryology attentively. Davidson eloquently articulates a real theory of the mechanism by which the genome computes the embryologic development of bilaterian animals. The argument is carefully developed from simple principles to more complex implications. The figures are a major part of the book's exposition, and repay very careful reading of the legends along with the associated text. The references are as current as 2006, so the book is quite cutting edge in its outlook. I heartily recommend it to any biologically sophisticated reader. It does presume elementary knowledge about biochemistry and molecular biology at about the freshman/sophomore college level. Enjoy!
| |
SIMILAR PRODUCTS |
| An Introduction to Systems Biology: Design Principles of Biological Circuits (Chapman & Hall/CRC Mathematical & Computational Biology)
by Uri Alon (Author)
Thorough and accessible, this book presents the design principles of biological systems, and highlights the recurring circuit elements that make up biological networks. It provides a simple mathematical framework which can be used to understand and even design biological circuits. The textavoids specialist terms, focusing instead on several well-studied biological systems that concisely demonstrate key principles. An Introduction to Systems Biology: Design Principles of Biological...
| 
| Epigenetics
by C. David Allis (Author), Thomas Jenuwein (Author), Danny Reinberg (Author), Marie-Laure Caparros (Author)
The regulation of gene expression in many biological processes involves epigenetic mechanisms. In this new volume, 24 chapters written by experts in the field discuss epigenetic effects from many perspectives. There are chapters on the basic molecular mechanisms underpinning epigenetic regulation, discussion of cellular processes that rely on this kind of regulation, and surveys of organisms in which it has been most studied. Thus, there are chapters on histone and DNA methylation, siRNAs...
| 
| Computational Modelling Of Gene Regulatory Networks -- A Primer
by Hamid Bolouri (Author)
This book serves as an introduction to the myriad computational approaches to gene regulatory modeling and analysis, and is written specifically with experimental biologists in mind. Mathematical jargon is avoided and explanations are given in intuitive terms. In cases where equations are unavoidable, they are derived from first principles or, at the very least, an intuitive description is provided. Extensive examples and a large number of model descriptions are provided for use in both...
| 
| Coming to Life: How Genes Drive Development
by Christiane Nusslein-Volhard (Author)
Christiane Nüsslein-Volhard, winner of The Nobel Prize in Medicine, gives a concise and illustrative overview of genetics, evolution, and cellular processes as well as a discussing of current ethical issues in human biology.
Coming to Life is a remarkable journey through developmental biology that reveals miraculous processes in the microscopic world of cells. Through an accounting of groundbreaking discoveries, Christiane Nüsslein-Volhard tells us many answers to historical and...
| 
| Evolutionary Dynamics: Exploring the Equations of Life
by Martin A. Nowak (Author)
At a time of unprecedented expansion in the life sciences, evolution is the one theory that transcends all of biology. Any observation of a living system must ultimately be interpreted in the context of its evolution. Evolutionary change is the consequence of mutation and natural selection, which are two concepts that can be described by mathematical equations.Evolutionary Dynamics is concerned with these equations of life. In this book, Martin Nowak draws on the languages of biology and...
|
|
|
