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| View Larger Image | Principles of Protein X-Ray Crystallography (Springer Advanced Texts in Chemistry) | Hardcoverby Jan Drenth (Author)
| List Price: | $89.95 | | Price: | $58.03 | | You Save: | $31.92 (35%) | | | Available: | Usually ships in 24 hours |
| | Binding: | Hardcover | | Publisher: | Springer | | Edition: | 3rdrd Edition | | Page Count: | 332 Pages | | Publication Date: | November 09, 2006 | | Sales Rank: | 558,931th |
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ACCESSORIES |
| Protein Interactions: Biophysical Approaches for the Study of Complex Reversible Systems (Protein Reviews)
by Peter Schuck (Editor)
This volume, part of the Protein Reviews book series, will successfully and clearly examine how biophysical approaches can be used to study complex systems of reversibly interacting proteins. It will deal with the methodology behind the research and how to synergistically incorporate several methodologies for use. The study of complex systems cannot be described or summarized in the abstract; therefore, each chapter would treat and introduce the reader to different biological systems, include a...
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| Phenolic Compound Biochemistry
by Wilfred Vermerris (Author), Ralph Nicholson (Author)
How does the consumption of red wine reduce heart disease? How does a plant battle an invading fungus using physical and chemical defense mechanisms? How are tannins used in leather production synthesized? These are just a few examples that illustrate the chemical diversity and use of phenolic compounds, the topic of ‘Phenolic Compound Biochemistry’. This book is written for researchers, instructors, advanced undergraduate students and beginning graduate students in the...
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EDITORIAL REVIEWS |
Product Description
X-ray crystallography has long been a vital method for studying the structure of proteins and other macromolecules. As the importance of proteins continues to grow, in fields from biochemistry and biophysics to pharmaceutical development and biotechnology, many researchers have found that a knowledge of X-ray diffraction is an indispensable tool. In this new edition of his essential work, Dr. Jan Drenth, recognized internationally for his numerous contributions to crystallographic research, has provided an up-to-date and technically rigorous introduction to the subject. "Principles of Protein X-ray Crystallography" provides the theoretical background necessary to understand how the structure of proteins is determined at atomic resolution. It is intended to serve as an introduction for graduate students, postdoctoral researchers, and established scientists who want to use protein crystallography in their own endeavors, or need to understand the subject in order to critically evaluate the literature. New additions to the book include a section on twinning, an additional chapter on crystal growth and a discussion of single-wavelength anomalous dispersion (SAD). Dr. Jan Drenth is a professor emeritus at the Laboratory of Biophysical Chemistry at the University of Groningen, The Netherlands. Contributing author Dr. Jeroen R. Mesters Ph.D. is a Senior Research Assistant at the Institute of Biochemistry, University of Luebeck, Germany. |
CUSTOMER REVIEWS (Average Customer Rating: 3.5 based on 3 reviews)
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Depends on who you are and what you want... by gani999 (Grenoble, France)  4 Stars
September 28, 2007
Jan Drenth is an old school protein crystallographer who has seen the evolution of the field right from its inception in the 1950s to the present day. He belongs to the era when Protein Crystallography was dominated by people with serious math and physics skills like Maurice Wilkins, Rosalind Franklin, Francis Crick, Max Perutz and John Kendrew. Owing to the lack of good computers in those days, all the calculations had to be done by hand and there was no way you could solve a protein structure if you didn't know what a Fourier Transform was. The situation is very different nowadays where, thanks to computers, even a person who doesn't know how to differentiate a function can solve protein structures.
Understandably, owing to the author's experiences and background, this book is an excellent one for people interested in the real math behind protein crystallography. It is much on the lines of the other classic book by Blundell and Johnson, also crystallographers belonging to the same era as Jan Drenth. It is quite full of mathematics and therefore, is not recommended for biologists or chemists with weak math skills. For such people I would recommend other introductory books on the subject written by Gale Rhodes, David Blow and Alex McPherson. A good approach would be to learn the basics from these intoductory books and 'graduate' to Drenth's book later.
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Not Helpful for a introductory class by Matthew Bratkowski (Ithaca, NY USA)  1 Stars
December 07, 2006
I used this text book for an introductory graduate class in X-ray Crystallograhy. After taking a semester of X-ray Crystallograhy (which is labeled as a Chemistry and Biochemistry course), I can say that the material is mainly based on physics and mathematics. I can't say that this text helped a great deal for my course. The text does not explain relevant points such as Miller indices, symmetry elements, or space groups clearly or in much depth. Instead, it spends too much time explaining concepts mathematically and deriving equations. It also does not contain any relevant practice problems, which are needed to understand Crystallography and practice for exams.
X-ray Crystallography is a very dense subject, and is not a course to take on a whim. I would not reccomend taking a course on Crystallography unless you have a really intense interest in pursuing research in that area. If you are interested in this area, do not buy this text even if it is required for your course. Take a look at Crystallography Made Crystal Clear by Gale Rhodes. That book is much clearer, though also lacks sufficient practice problems.
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Best introductory text  5 Stars
April 17, 2001
Best introductory text for macromolecular xray crystallography. Simple and succinct mathematical explanation of basic concepts. It provides enough background for students to start a research project.
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SIMILAR PRODUCTS |
| Crystallography Made Crystal Clear, Third Edition: A Guide for Users of Macromolecular Models (Complementary Science)
by Gale Rhodes (Author)
Crystallography Made Crystal Clear makes crystallography accessible to readers who have no prior knowledge of the field or its mathematical basis. This is the most comprehensive and concise reference for beginning Macromolecular crystallographers, written by a leading expert in the field. Rhodes' uses visual and geometric models to help readers understand the mathematics that form the basis of x-ray crystallography. He has invested a great deal of time and effort on World Wide Web tools for...
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| Outline of Crystallography for Biologists
by David Blow (Author)
Outline of Crystallography for Biologists is intended for researchers and students in the biological sciences who require an insight into the methods of X-ray crystallography without needing to learn all the relevant theory. The main text is purely descriptive and is readable by those with minimal mathematical knowledge. Some mathematical detail is given throughout in boxes, but these can be ignored. Theory is limited to the essentials required to comprehend issues of quality. There is an...
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| Practical Protein Crystallography, Second Edition
by Duncan E. McRee (Author)
Designed for easy use by both beginning and experienced protein crystallographers, the second edition of Practical Protein Crystallography is an essential handbook for any scientist interested in solving a protein structure. The book includes examples of actual experiments and data, electron density maps, and computer methods. This second edition has new material covering CCP4, SHELX, cryocrystallography, MAD and automated fitting.
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| Introduction to Macromolecular Crystallography
by Alexander McPherson (Author)
A comprehensive and approachable introduction to crystallography — now updated in a valuable new edition The Second Edition of this well-received book continues to offer the most concise, authoritative, and easy-to-follow introduction to the field of crystallography. Dedicated to providing a complete, basic presentation of the subject that does not assume a background in physics or math, the book's content flows logically from basic principles to methods, such as those for solving...
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| Three-Dimensional Electron Microscopy of Macromolecular Assemblies: Visualization of Biological Molecules in Their Native State
by Joachim Frank (Author)
Cryoelectron microscopy of biological molecules is among the hottest growth areas in biophysics and structural biology at present, and Frank is arguably the most distinguished practitioner of this art. CryoEM is likely over the next few years to take over much of the structural approaches currently requiring X-ray crystallography, because one can now get good and finely detailed images of single molecules down to as little as 200,000 MW, covering a substantial share of the molecules of greatest...
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