| View Larger Image | Inflammation in the Pathogenesis of Chronic Diseases: The COX-2 Controversy (Subcellular Biochemistry) | Hardcoverby Randall E. Harris (Author), Randall E. Harris (Editor)
| List Price: | $199.00 | | Price: | $159.20 | | You Save: | $39.80 (20%) | | | Available: | Usually ships in 24 hours |
| | Binding: | Hardcover | | Publisher: | Springer | | Edition: | 1st Edition | | Page Count: | 344 Pages | | Publication Date: | May 18, 2007 | | Sales Rank: | 1,108,115st |
|
ACCESSORIES |
| Cytokines in the Genesis and Treatment of Cancer (Cancer Drug Discovery and Development)
by Michael A. Caligiuri (Editor), Michael T. Lotze (Editor)
Cytokines in the Genesis and Treatment of Cancer provides a comprehensive picture of the dual role of host responses in promoting and inhibiting tumor progression. This volume represents an important investigation into the emerging intersection of cancer biology and cancer immunology. Divided into four sections, the volume’s first three parts focus on cytokines in the genesis of cancer. The final section describes the notable progress — both in animal models and humans — in demonstrating...
| 
| Regional Cancer Therapy (Cancer Drug Discovery and Development)
by Peter M. Schlag (Editor), Ulrike Stein (Editor), M.M. Eggermont (Editor)
This volume provides a biological and pharmacological background for regional cancer therapy, strategies and techniques for regional therapies, and specific indications and results for different tumor entities. Clinical trial concepts and detailed treatment protocols are also presented. Part I describes biological and pharmacological fundamentals for therapy and introduces laboratory models for isolated limb and organ perfusion. Topics introduced in Part II include interventional...
| 
| Acute Promyelocytic Leukemia: Molecular Genetics, Mouse Models and Targeted Therapy (Current Topics in Microbiology and Immunology)
by Pier Paolo Pandolfi (Editor), Peter K. Vogt (Editor)
Over the past 10 years, work on acute promyelocytic leukemia (APL) has become the paradigm of translational research that began with the discovery of a recurrent chromosomal translocation, followed by the identification of the genes and proteins involved, finding their molecular functions in transcriptional control, establishing mouse models and culminating in the development of targeted therapy.
|
|
EDITORIAL REVIEWS |
Product Description
The authors provide exciting and enlightening perspectives on COX-2 and related molecular targets in the future of medicine, including historical perspectives on the discovery and development of aspirin, ibuprofen, and compounds that selectively inhibit COX-2, and the potential for development of new compounds with better efficacy and safety in the 21st century. Specific chapters illuminate the role of inflammatory mechanisms in the pathogenesis of arthritis, cardiovascular disease, cancer, neurodegenerative disease, diabetes mellitus, obesity, and other life-threatening and debilitating conditions. Experts in cardiovascular medicine explore the "COX-2 controversy" regarding adverse effects of some (not all) selective COX-2 inhibitors on the cardiovasculature. Important findings are documented in cancer research showing that selective COX-2 inhibitors have powerful antineoplastic effects against major forms of cancer. A special section explores the current evidence supporting the role of COX-2 and inflammation in the development of Alzheimer s disease and other neurodegenerative conditions and the potential benefit of compounds that modulate COX-2 and other inflammatory cytokines. The final section addresses nutritional modulation of inflammation and the chemopreventive value of anti-inflammatory nutraceutical agents. |
|
