Product Description
This is a AIR FORCE INST OF TECH WRIGHT-PATTERSON AFB OH report procured by the Pentagon and made available for public release. It has been reproduced in the best form available to the Pentagon. It is not spiral-bound, but rather assembled with Velobinding in a soft, white linen cover. The Storming Media report number is A137813. The abstract provided by the Pentagon follows: This thesis considers the problem of statistically evaluating the closeness of multiple genes based on their DNA intronic regions. The purpose of intronic regions in a gene is unknown. Recent research suggests that, in cancer related genes, intronic regions may play a role in regulating disease susceptibility. To investigate whether the intronic features of cancer related genes differ from non-regulatory genes, a collection of oncogenes, tumor suppressor genes, and non- regulatory genes involved in enzyme metabolism are analyzed. A statistical methodology is employed to determine whether features of these genes' intronic regions will result in clustering by regulatory group. This is the first comparison of intronic attributes for 33 homo sapien genes. Affributes analyzed include mean of intronic log lengths, standard deviations of intronic log lengths and number of intronic regions in a gene. The analysis also includes the available ordered DNA data from these intronic regions. The process begins with creation of first-order Markov transition counts for all intronic regions in each gene. A hypothesis testing approach employs these counts to determine whether the order of the nucleotides in each intronic region is random or whether this order shows statistical evidence of a first-order Markov chain. |
