| View Larger Image | Physiological Responses to Intermittent Hypoxia in Humans | Paperbackby Jon C. Kolb (Author)
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| | Binding: | Paperback | | Publisher: | Dissertation.Com. | | Page Count: | 196 Pages | | Publication Date: | October 15, 2004 | | Sales Rank: | 2,425,727nd |
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The goal of this dissertation is to provide a detailed investigation into the physiologic and symptomatic responses following an intervention of discontinuous normobaric hypoxia, which employs portable chambers. To accomplish this, an intermittent protocol was developed which cycled between 8 hrs of nocturnal hypoxia at a simulated altitude of 4300m, followed by 16 hrs of normoxia, for five consecutive days. Specifically, it is not currently known if cerebrovascular and ventilatory sensitivities to acute hypoxia are altered, or if altitude-like symptoms develop, in response to such an intermittent hypoxic protocol. From the studies described, the main conclusions are that an intermittent normobaric hypoxic intervention, consisting of five consecutive overnight exposures to a simulated altitude of 4300m, elicits perturbations in the acute cerebrovascular and ventilatory responses to both hypoxia and hypercapnia, which are similar to changes following chronic altitude exposure. Individual variability to intermittent hypoxia may have an impact on the rate at which the process of acclimatization proceeds. The extent of physiological and symptomatic responses to intermittent hypoxia are likely to be associated with the severity of hypoxia as well as the length and number of recurrent episodes of hypoxia. |
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