| View Larger Image | Death Receptors in Cancer Therapy (Cancer Drug Discovery and Development) | Hardcoverby Wafik S. El-Deiry (Editor)
| List Price: | $175.00 | | | Available: | Usually ships in 24 hours |
| | Binding: | Hardcover | | Publisher: | Humana Press | | Edition: | 1st Edition | | Page Count: | 384 Pages | | Publication Date: | December 03, 2004 | | Sales Rank: | 3,238,126rd |
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EDITORIAL REVIEWS |
Product Description
An in depth review of our latest understanding of the molecular events that regulate cell death and those molecules that provide targets for developing agonists or antagonists to modulate death signaling for therapeutic purposes. The authors focus on the extrinsic system of death receptors, their regulation and function, and their abnormalities in cancer. Topics of particular interest include resistance to apoptosis, TRAIL signaling, death receptors in embryonic development, mechanisms of caspase activation, and death receptor mutations in cancer. Additional chapters address death signaling in melanoma, synthetic retinoids and death receptors, the role of p53 in death receptor regulation, immune suppression of cancer, and combination therapy with death ligands. |
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