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| View Larger Image | Gene Silencing: New Research | Hardcoverby Grace W. Redberry (Editor)
| List Price: | $160.00 | |
| | Binding: | Hardcover | | Publisher: | Nova Science Publishers | | Edition: | 1st Edition | | Page Count: | 201 Pages | | Publication Date: | April 14, 2006 | | Sales Rank: | 6,852,036th |
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EDITORIAL REVIEWS |
Product Description
Gene silencing is a general term describing epigenetic processes of gene regulation. The term gene silencing is generally used to describe the 'switching off' of a gene by a mechanism other than genetic mutation. That is, a gene which would be expressed (turned on) under normal circumstances, is switched off by machinery in the cell. Genes are regulated at either the transcriptional or post-transcriptional level. Transcriptional gene silencing is the result of histone modifications, creating an environment of heterochromatin around a gene that makes it inaccessible to transcriptional machinery (RNA polymerase, transcription factors, etc.). Post-transcriptional gene silencing is the result of mRNA of a particular gene being destroyed. The destruction of the mRNA prevents translation to form an active gene product (in most cases, a protein). A common mechanism of post-transcriptional gene silencing is RNAi. Both transcriptional and post-transcriptional gene silencing are used to regulate endogenous genes. This book presents the latest research in this important field. |
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