| View Larger Image | Natural Killer T-Cells: Roles, Interactions, and Interventions | Hardcoverby Nathan V. Fournier (Editor), Tomer Adar (Editor), Walter Barberi (Editor), Ami Ben Ya'acov (Editor), Felipe Diaz-Giffero (Editor)
| List Price: | $129.00 | | | Available: | Temporarily out of stock. Order now and we'll deliver when available. We'll e-mail you with an estimated delivery date as soon as we have more information. Your credit card will not be charged until we ship the item. |
| | Binding: | Hardcover | | Publisher: | Nova Science Publishers | | Edition: | illustrated editionth Edition | | Page Count: | 203 Pages | | Publication Date: | July 30, 2008 | | Sales Rank: | 2,466,821nd |
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Product Description
Natural killer T (NKT) cells are a heterogeneous group of T cells that share properties of both T cells and natural killer (NK) cells. Many of these cells recognize the non-polymorphic CD1d molecule, an antigen-presenting molecule that binds self and foreign lipids and glycolipids. Upon activation, NK T cells are able to produce large quantities of interferon-gamma, IL-4, and granulocyte-macrophage colony-stimulating factor, as well as multiple other cytokines and chemokines (such as IL-2 and TNF-alpha). NKT cells seem to be essential for several aspects of immunity because their dysfunction or deficiency has been shown to lead to the development of autoimmune diseases (such as diabetes or atherosclerosis) and cancers. NKT cells have recently been implicated in the disease progression of human asthma. The clinical potential of NKT cells lies in the rapid release of cytokines (such as IL-2, IFN-gamma, TNF-alpha, and IL-4) that promote or suppress different immune responses. |
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