| View Larger Image | Deep Brain Stimulation: A New Treatment Shows Promise in the Most Difficult Cases | Hardcoverby Jamie Talan (Author)
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| | Binding: | Hardcover | | Publisher: | Dana Press | | Edition: | 1st Edition | | Page Count: | 200 Pages | | Publication Date: | February 15, 2009 | | Sales Rank: | 280,665th |
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FEATURES | - ISBN13: 9781932594379
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EDITORIAL REVIEWS |
Product Description
There are disorders that defy treatment with prescribed pharmaceuticals: a man’s hands shake so hard that he cannot hold anything; a woman is mired in severe inescapable depression. For these patients and others, an alternative is emerging: deep brain stimulation. In this fascinating and timely investigation, well-known science writer Jamie Talan explains a cutting-edge medical development that is surprising and impressing researchers around the world. More than 40,000 people worldwide have undergone deep brain stimulation, which involves implanting electrodes in the brain that are connected to a device similar to a pacemaker. With compelling profiles of patients and an introduction to doctors and scientists who are pioneering the research, Talan describes the ways in which deep brain stimulation has produced promising results in the treatment of diseases such as Parkinson’s disease, depression, obsessive-compulsive disorder, and dystonia—as well as the ethical issues that have arisen in the course of this research. |
CUSTOMER REVIEWS (Average Customer Rating: 4.5 based on 5 reviews)
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A new treatment method for brain disease by Kisueng Choi  4 Stars
September 28, 2009
As a student of bioscience, I find this book to be comprehensive in deep brain stimulation (DBS) topic with a simple, but concise understanding. Deep Brain Stimulation by Jamie Talan takes us to the forefront of brain research with an accessible introduction to a new treatment method for disparate brain diseases such as Parkinson's disease, dystonia, obsessive-compulsive disorder, chronic pain, and even states of long-term unconsciousness. This book provides readers with an inside look on the revolutionary technology by tracking history, presenting latest developments from preeminent scientists, and providing firsthand accounts from patients.
The first part of the book describes of pioneers and histories in the DBS research field with Parkinson's disease. Parkinson's disease is one of the best studied brain disorder by the end of twentieth century and has long history with human life. The book shows us many frontiers and their successful researches such as Rolf Hassler and Lauri Laitinen, who are neurosurgeons and focused on thalamus surgery for treatment of Parkinson's tremor, and Irving S. Cooper, who operated on more than five thousands surgery for Parkinson's patients. Even though the results were unsuccessful, these efforts provided a starting point to understand the disease and moved one step closer to the brain regions that are related to Parkinson's tremor.
After some period of this controversy on the frontiers, George C. Cotzias developed a precursor of dopamine called L-dopa. He shows that L-dopa crossed into the brain broke down to form the dopamine needed to restore levels of the chemical to the basal ganglia. This region was normally rich with dopamine, but in the Parkinson's patients, dopamine was depleted from the cells. Over two decades, patients had been relying on L-dopa to treat their symptoms, but the medicine was proving to have its own problems such as on and off fluctuations, and dopamine cells in the brain continued to die away.
The patients unable to benefit in the long-term from L-dopa, it remained for researchers to produce one more series advances that would open the road to DBS. Those advances would emerge from confluence of neurosurgery and revelations from microrecording of brain cells by Dr. Delong. He and his team are focused on microrecorduing of brain and applied pillidotomy to the basal ganglia. They proved that the surgical lesion in the pallidum worked better than medications, reducing symptoms by 30 percent more than the drugs.
In November 1986, Dr. Benabid found that electrical stimulation with high frequency can stop the patient's tremor. When he applied stimulation on STN based on the results of Dr. Delong, he found at least resting tremors had gone. For more than twenty years since the mid-1980s, pioneering leadership-by DeLong, Laitinene, Benabid, and Vitek most notably-had been setting the landmarks by which deep brain stimulation could begin to advance.
For dystonia, researchers have more hard time to figure out the effects of DBS treatment because responding time of DBS treatment is not same as Parkinson's. When they implanted electrode, they can see the results immediately. However, a few months later after patient had a surgery, the patient starts to respond and the symptoms are reduced by more than 50 percent.
People marvel at the concept of DBS when they see someone with advanced Parkinson's, who is no longer jerking and can walk smoothly, or a young boy out playing basketball again after being unable even to sit in a wheelchair without falling to the ground because of dystonia. But then mention that neurosurgeons and neurologists have teamed up with psychiatrists to tackle obsessive-compulsive disorder (OCD), Tourette syndrome, or depression, and there is a look of consternation."Stimulation the brain to alter behavior and mood?" the researchers start with this sentence and notice that such side effects of DBS had been created changes in mood and behaviors. The OCD patients with DBS had improved almost 65 percent on their symptoms. For the Depression and Tourette symdrome, DBS is still not clear because some of patients are getting better but the orders are not. In addition, the brain regions related to these psychiatric disorders are not clear enough. The researchers think DBS does not only activate the output from stimulated structure but also changes the pattern of neuronal activity from a noisy, chaotic signal to a more regular one. This pattern change may be the key to find out DBS for depression and Tourette syndrome, but notes much remain to be done to understand the effects on the network and how it may change with long-term stimulation.
Finally, the author touches the parameters and risks for DBS treatment. DBS techniques have developed for each condition the benefits always have emerged hand in hand with the side effects and the risks. The problem is that DBS is not just a surgery but a technique that needs to be done just right and sometimes adjusting the parameters of the stimulation can take months, or even longer. The neurosurgeon and neurologist have to keep their eyes wide open and look at patients for best treatment with DBS.
After finishing the book, it seems to deserve at least a four out of five star rating, the amount of information gained on major history of DBS and its effects on Parkinson's disease, dystonia, and psychiatric disorders are satisfying. Although the author offers multiple examples to illustrate his point, it is at a great difficulty to comprehend for non-field related readers. In essence, more than 40,000 patients around the world have undergone DBS. Most have experienced remarkable improvement, and news of successes has been reported widely. Yet between brain and device are ambushes and challenges less often captured, and they are crucial to a clearer understanding of what doctors and scientist mean by breakthrough. I highly recommend this book to those who are interested in brain disorder and new treatment methods.
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dbs by Cindy (pa) 4 Stars
August 30, 2009
very interesting book people that don't know about dystonia or parkinson's disease should read this book
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Discusses a new technology of electrodes implanted in the brain and attached to a battery by Midwest Book Review (Oregon, WI USA)  5 Stars
April 14, 2009
DEEP BRAIN STIMULATION: A NEW TREATMENT SHOWS PROMISE IN THE MOST DIFFICULT CASES is a pick for any medical collection: it discusses a new technology of electrodes implanted in the brain and attached to a battery that alleviates suffering. Over 40,000 patients around the world have undergone this - both successes and cautions are detailed in a survey of experiments using DBS to treat various disorders.
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Excellent read by Dr. Rob (Hershey, PA) 5 Stars
April 02, 2009
As one of the first patients to undergo DBS for Dystonia (2001), and was one of the case histories Jamie discussed, I truly enjoyed the book. Talan writes in an easy to read manner, and describes the truly amazing potential, and potential pitfalls, of this novel treatment. As DBS becomes more well publicized, this book will be a go-to reference for the lay person. It is a quick read because it is not overly technical, and is well suited for the non-scientific reader.
If you want to hear her discussion of the book on NPR, you can go to http://www.wnyc.org/flashplayer/player.html#/play/%2Fstream%2Fxspf%2F127486.
Kudos to Jamie Talan for bringing this treatment to the public consciousness.
(NOTE: I am NOT financially involved in this book in any way whatsoever.)
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Enlightening by Susan R. Rubin (nebraska) 5 Stars
March 07, 2009
I found this book inspiration because it gave hope for a treatment option for Parkinson's
disease and other hard to treat disease states where there was often no options. Talan has the gift of describing a scientifically detailed treatment in terms that I could understand and at the same time providing valuable new information for medical professionals. The personalized case studies made the book an even easier and believable read. Talan put Deep Brain Stimulation on the map to the public and medical community as well.
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