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| View Larger Image | Advances in Multiple Sclerosis and Experimental Demyelinating Diseases (Current Topics in Microbiology and Immunology) | Hardcoverby Moses Rodriguez (Author), Moses Rodriguez (Editor)
| List Price: | $189.00 | | | Available: | Usually ships in 24 hours |
| | Binding: | Hardcover | | Publisher: | Springer | | Edition: | 1st Edition | | Page Count: | 362 Pages | | Publication Date: | December 18, 2007 | | Sales Rank: | 2,125,857nd |
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EDITORIAL REVIEWS |
Product Description
There is a need for a paradigm shift in our thinking about the pathogenesis of multiple sclerosis. Challenging Charcot s hypothesis that inflammatory response is the primary contributor to demyelination, Dr. Rodriguez and colleagues take a fresh, bold look at the causes and possible treatments of MS. Assuming oligodendrocyte injury as a prerequisite to MS, the authors explore viruses, toxins and genetic defects as possible culprits. They present novel methods to interrupt and reverse demyelination. This book examines the correlation between axonal loss and clinical deficits, including the implied role of the CD8+ T cell and perforin. It assesses proteases, specifically, kallikrein 6, which are strongly associated with active demyelination. By directing natural autoantibodies against oligodendrocytes that demonstrate remyelination in animal models, the authors envision clinical trials for remyelination enhancement. As internationally recognized specialists in a wide range of MS disciplines, the authors explore genetic tools for identifying patients who are most likely to experience spontaneous remyelination. Epidemiology studies offer additional avenues of treatment. Examples include uric acid, statin drugs, estrogen and progesterone. MS affects nearly 400,000 people in the United States, many of whom are between18 and 40 years of age. With their novel, multifaceted approach to basic science and their applications in understanding cause and treatment the authors offer help to clinicians and hope to patients. |
SIMILAR PRODUCTS |
| Multiple Sclerosis: Immunology, Pathology and Pathophysiology
by Robert M. Herndon (Author)
Univ. of Mississippi, Jackson. Provides an overview of the basic sciences as they relate to MS. Companion text to, Multiple Sclerosis: Diagnosis, Medical Management, and Rehabilitation by Jack S. Burks, c2000. Includes halftone charts, and illustrations. Topics include morphologic substrates of demyelination, experimental aspects, and more. DNLM: Multiple Sclerosis--immunology.
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| Multiple Sclerosis As A Neuronal Disease
by Stephen Waxman (Author)
This book examines the role of neurons in multiple sclerosis (MS) and the changes that occur in neurons as a result of MS. It places MS in a new and important perspective that not only explains the basis for symptom production, remission, and progress in MS, but also promises to open up new therapeutic possibilities.
* Brings together the latest information from clinical, pathological, imaging, molecular, and pharmacological realms to explore the...
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