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| View Larger Image | Cancer Stem Cells, Immunotherapy: An Intergrated Approach to Cancer Treatment | Paperbackby Obdulio Piloto (Author)
| List Price: | $67.00 | | Price: | $52.20 | | You Save: | $14.80 (22%) | | | Available: | Usually ships in 24 hours |
| | Binding: | Paperback | | Publisher: | VDM Verlag Dr. Müller | | Page Count: | 100 Pages | | Publication Date: | January 09, 2009 | | Sales Rank: | 1,932,383st |
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EDITORIAL REVIEWS |
Product Description
Our knowledge of cancer initiation, progression and treatment has dramatically increased over the last decade. This understanding promises to deliver novel therapeutic agents that will eliminate the burden of the disease on individuals, families and society. However, early impressive clinical results are often overshadowed by relapse and the development of resistance. Recent studies strongly support the notion that at least some cancers are initiated, maintained and disseminated by cancer stem cells. These cells possess properties of normal stem cells and are typically less responsive to current therapies, thus explaining the observed resistance. Based on the cancer stem cell theory, the elimination of these cancer stem cells is imperative if we are to cure patients. A number of aberrantly activated proteins have been found critical for the proliferation and/or survival of cancer stem cells, one of which is the mutant FLT3 receptor, expressed on leukemia stem cells. This book uses FLT3 as an example to illustrate the development of targeted therapeutics, mechanisms of resistance and strategies to overcome resistance. |
CUSTOMER REVIEWS (Average Customer Rating: 5.0 based on 1 review)
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Thought provoking by Ta C. Chang (San Francisco, CA)  5 Stars
January 21, 2009
A compact treatise on recent innovations in cancer resistance and immunotherapy, full of fresh insights and novel ideas. Highly recommended to all who work in related fields.
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