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| View Larger Image | MOLECULAR MECHANISMS OF HIV-1 LATENCY: Nature and Impact of HIV-1 Integration Sites | Paperbackby Yefei Han (Author)
| List Price: | $66.00 | | | Available: | Usually ships in 24 hours |
| | Binding: | Paperback | | Publisher: | VDM Verlag Dr. Müller | | Page Count: | 116 Pages | | Publication Date: | January 13, 2009 | | Sales Rank: | 5,506,279th |
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EDITORIAL REVIEWS |
Product Description
Advances in the treatment of HIV-1 infection with highly active anti-retroviral therapy (HAART) have greatly reduced mortality and changed this fatal infection into a chronic disease for many. HAART can reduce viremia to below the clinical limit of detection. However, eradication of the infection has not been achieved. HIV-1 can establish latent infection in a small pool of resting memory T cells in which the provirus is stably integrated into the host genome but not producing viral proteins. This state of latency allows HIV-1 to evade immune responses and antiretroviral drugs. Upon cellular activation, replication-competent viruses can be quickly released from the latent reservoir to rekindle the infection. Because of its extremely slow decay rate, the latent reservoir is a major barrier to curing HIV-1 infection. Dr. Han¿s dissertation explored the molecular mechanisms underlying this unique nature of the infection in resting CD4+ T cells, starting from the first in vivo analysis of integration sites in resting CD4+ T cells to the novel discovery of the bidirectional regulation on integrated HIV-1 by the host gene transcriptional read-through. |
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