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| View Larger Image | A Proteomic Approach for Bordetella Pertussis: Identification of the New Immunogenic Proteins of Bordetella pertussis, the Causative Agent of Whooping Cough, by Immunoproteomics | Paperbackby EMRAH ALTINDIS (Author)
| List Price: | $65.00 | | | Available: | Usually ships in 24 hours |
| | Binding: | Paperback | | Publisher: | VDM Verlag | | Page Count: | 120 Pages | | Publication Date: | April 26, 2009 | | Sales Rank: | 5,065,144th |
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Product Description
The genus Bordetella contains several pathogenic species generally associated with upper respiratory tract infections in warm-blooded animals. Bordetella pertussis is the etiologic agent of whooping cough. Whooping cough is presently one of the ten most common causes of death from infectious diseases and reported by the World Health Organisation (WHO) to cause 50 million cases and 350000 deaths worldwide per year. The term proteome, in analogy to the term genome, was coined to describe the complete set of proteins that an organism has produced under a defined set of conditions. Proteomics has been used to identify novel bacterial vaccine candidates against several human pathogens. Much of information about immunogenic component can be derived from proteomics coupled to Western blotting, namely immunoproteomics. In the present study, we report first immunoproteomics analysis to identify candidate antigens of B. pertussis for vaccine development. Different sera from mice, which were immunized or challenged with B. pertussis, were analyzed for reactivity by Western blot against whole cell extracts of B. pertussis Tohama and Saadet strains separated by 2-DE. |
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