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| View Larger Image | Presynaptic control of sensory input on the mammalian olfactory system: In vivo modulation of olfactory receptor neuron input to the mouse olfactory bulb ... activity-dependent presynaptic inhibition | Paperbackby Nicolás Pírez (Author)
| List Price: | $82.00 | | | Available: | Usually ships in 24 hours |
| | Binding: | Paperback | | Publisher: | VDM Verlag | | Page Count: | 132 Pages | | Publication Date: | June 21, 2009 | | Sales Rank: | 4,772,052th |
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Product Description
Presynaptic inhibition modulates signal transmission in the olfactory pathway by several mechanisms, a major one being mediated by GABAB receptors, which suppress presynaptic calcium influx and subsequent transmitter release from the receptor neuron terminal. Presynaptic inhibition could function to limit the strength of olfactory input to the central nervous system, as well as provide a substrate for centrifugal control of odorant representations early in the olfactory system. Odorant and electrical stimulation combined with in vivo pharmacology were used to characterize the functional determinants of GABAB-mediated presynaptic. The results of this work showed that tonic inhibition is a major determinant of receptor input strength; and were dependent on glutamatergic transmission from second-order neurons in the glomerular layer. When the behavioral state of the awake animal was altered, odorant-evoked responses were affected. Taken together these results suggest that tonic inhibition via top-down, centrifugal control plays a major role in modulating the magnitude of sensory input to the brain as a function of behavioral state. |
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