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| View Larger Image | Glial cells in the enteric nervous system: Plasticity of glial cells in the enteric nervous system during intestinal inflammation | Paperbackby Sebastian Hoff (Author)
| List Price: | $110.00 | | | Available: | Usually ships in 24 hours |
| | Binding: | Paperback | | Publisher: | Suedwestdeutscher Verlag fuer Hochschulschriften | | Page Count: | 148 Pages | | Publication Date: | May 27, 2009 |
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EDITORIAL REVIEWS |
Product Description
Enteric glial cell (EGC) markers were thoroughly characterized in the human enteric nervous system (ENS) and EGC numbers were compared in man and guinea pig. As a result, the Sox8/9/10 antibody was shown to be an excellent investigative tool to assess EGC in the ENS and the glia index was identified as the most robust quantitative descriptor within a species. Subsequently, this Sox8/9/10 was used in Crohn´s disease specimens to quantify enteric glia. In a parallel approach, interactions of EGC and the intestinal epithelial barrier were analyzed. Results from these experiments indicate a protective effect of EGCs on the intestinal epithelial barrier in intestinal inflammation. The observed expression of GDNF, NGF, NT-3 and their receptors by EGC points to promising targets for further research to elucidate the exact nature of glial-derived mucosa-protective factors. |
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