| View Larger Image | Ligand & Electrically Induced Activation Patterns in Myenteric Neuronal Networks: Confocal Calcium Imaging As a Bridge Between Basic & Human Physiology (Acta Biomedica Lovaniensia) | Paperbackby Raf Bisschops (Author)
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| | Binding: | Paperback | | Publisher: | Leuven Univ Pr | | Page Count: | 134 Pages | | Publication Date: | May 31, 2005 |
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Product Description
This is a Ph.D. dissertation. Gastrointestinal motility regulated by hormonal, myogenic and neuronal mechanisms. The neuronal control consists of two elements: on the one hand the extrinsic innervation by para- and ortho-sympathetic nerve fibres and on the other hand intrinsic intrinsic innervation by the enteric nervous system (ENS). The myenteric plexus as part of the ENS, is to a great extent involved in the control of gastrointestinal motility. The guinea-pig myenteric plexus has been the subject of intense research over the last three decades, resulting in a better understanding of gastrointestinal physiology and motility. The ENS comprises a large diversity of neurons. Current classification schemes of enteric neurons are mainly based on the data obtained from classical electrophysical experiments, immunohistochemistry and retrograde labeling techniques. Electrophysiological recordings give real-time information concerning the electrical activity of one impaled myenteric neuron (S/AH type neurons), but this information is mostly limited to a single neuron. Immunohistochemical staining for different neurotransmitters or different functionally relevant proteins provides information about an activity due to intrinsic technical limitations of fixation techniques. |
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