| View Larger Image | Effects of methotrexate on calcium flux in rat liver mitochondria, microsomes and plasma membrane vesicles [An article from: Comparative Biochemistry and Physiology, Part C] | Digitalby C.L.S. Pagadigorria (Author), F. Marcon (Author), A.M Kelmer-Bracht (Author)
| List Price: | $10.95 | | | Available: | Available for download now |
| | Binding: | Digital | | Publisher: | Elsevier | | Page Count: | 8 Pages | | Publication Date: | July 01, 2006 |
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Product Description
This digital document is a journal article from Comparative Biochemistry and Physiology, Part C, published by Elsevier in 2006. The article is delivered in HTML format and is available in your Amazon.com Media Library immediately after purchase. You can view it with any web browser.Description: The metabolic effects of methotrexate in perfused livers are similar to those exerted by hormones acting through Ca^2^+-dependent mechanisms. The aim of the present study was to determine whether the effects of methotrexate are mediated by a direct action on cellular Ca^2^+ fluxes. Methotrexate did not affect the ATP-dependent ^4^5Ca^2^+ uptake by mitochondria, microsomes and inside-out plasma membrane vesicles and Ca^2^+ efflux from plasma membrane vesicles. However, methotrexate was able to stimulate ^4^5Ca^2^+ release from preloaded microsomes. The amount of Ca^2^+ released by methotrexate was similar to that induced by IP"3. Methotrexate could be acting through the capacitative calcium entry mechanism. |
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