| View Larger Image | Arsenic-induced changes in optic tectal histoarchitecture and acetylcholinesterase-acetylcholine profile in Channa punctatus: Amelioration by selenium ... Biochemistry and Physiology, Part C] | Digitalby S. Roy (Author), A. Chattoraj (Author), S. Bhattacharya (Author)
| List Price: | $10.95 | | | Available: | Available for download now |
| | Binding: | Digital | | Publisher: | Elsevier | | Publication Date: | September 01, 2006 |
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Product Description
This digital document is a journal article from Comparative Biochemistry and Physiology, Part C, published by Elsevier in 2006. The article is delivered in HTML format and is available in your Amazon.com Media Library immediately after purchase. You can view it with any web browser.Description: Fish (Channa punctatus Bloch) were exposed in vivo for 14 days to non-lethal doses of As"2O"3 (10% LC"5"0 and 5% LC"5"0). Several endpoints related to histoarchitectural and acetylcholine-acetylcholinesterase (ACh-AChE) profile in the optic tectum were evaluated. Histological examination showed aggregated, disorganized and necrotic cells with irregular outlines in the different layers of optic tectum in the As-treated fish. The histopathological changes were more pronounced on day 7 than on other days and the damage was found to recover on day 14. ACh content and AChE activity demonstrated the usual inverse trend. Arsenic treatment was associated with a dose-dependent increase in AChE activity on day 1, a decrease on day 2 and reactivation on day 7, returning to the basal level on day 14. In vitro inhibition kinetics were set up to determine I"5"0 (35 @mM) concentration of As"2O"3. The ameliorative potential of selenium on arsenic-mediated inhibition of AChE revealed a positive role of Se, especially when Se preceded As"2O"3 treatment, either in vitro or in vivo. |
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