| View Larger Image | Allelic histories: positive selection on a HIV-resistance allele [An article from: Trends in Ecology & Evolution] | Digitalby M.P. Stumpf (Author), H.M. Wilkinson-Herbots (Author)
| List Price: | $4.95 | | | Available: | Available for download now |
| | Binding: | Digital | | Publisher: | Elsevier | | Publication Date: | April 01, 2004 | | Sales Rank: | 6,695,334th |
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Product Description
This digital document is a journal article from Trends in Ecology & Evolution, published by Elsevier in 2004. The article is delivered in HTML format and is available in your Amazon.com Media Library immediately after purchase. You can view it with any web browser.Description: The CCR5-@D32 allele crucially determines the course of HIV infection and appears to be highly protective against the disease. Population genetic studies suggest that the allele has been under positive selection in Europe in the past. In a recent paper, Alison Galvani and Montgomery Slatkin collate the available evidence and use a mathematical model to strongly suggest that smallpox could have exerted sufficient selection pressure to explain the distribution of the allele across Europe. This is a beautiful example of the power of mathematical models in evolutionary genetics. |
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