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| View Larger Image | Novel fluorescent silica nanoparticle probe for ultrasensitive immunoassays [An article from: Analytica Chimica Acta] | Digitalby W. Yang (Author), C. Zhang (Author), H. Qu (Author), H. Yang (Author), J. Xu (Author)
| List Price: | $8.95 | | | Available: | Available for download now |
| | Binding: | Digital | | Publisher: | Elsevier | | Publication Date: | February 09, 2004 |
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Product Description
This digital document is a journal article from Analytica Chimica Acta, published by Elsevier in 2004. The article is delivered in HTML format and is available in your Amazon.com Media Library immediately after purchase. You can view it with any web browser.Description: The preparation and utilization of a novel particulate label based on fluorescent hybrid silica (FHS) nanoparticles are reported in this article. These nanoparticles have shown several unique advantages over existing dye molecules, quantum dots, and latex-based fluorescent particles in easy preparation, good photostability and high sensitivity. A high molar ratio of the fluorescent molecules present in the core to biomolecules on the particle surface was achieved by using the well-developed silica surface immobilization chemistry for biomolecular linking. A fluoroimmunoassay method for detecting trace level Hepatitis B Surface Antigen (HBsAg) was developed. The calibration graph for HBsAg was linear over the range 0.5-220ng/ml with a detection limit of 0.1ng/ml. The sensitivity is greatly increased when compared with the corresponding immunoassay performed with direct fluorophore labeling. The present work shows that these FHS nanoparticles are high-quality markers for biochemical assays. |
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