| View Larger Image | Zinc and 17@b-estradiol induce modifications in Na^+/H^+ exchanger and pyruvate kinase activity through protein kinase C in isolated mantle/gonad cells ... Biochemistry and Physiology, Part C] | Digitalby M. Kaloyianni (Author), R. Stamatiou (Author), S. Dailianis (Author)
| List Price: | $10.95 | | | Available: | Available for download now |
| | Binding: | Digital | | Publisher: | Elsevier | | Publication Date: | July 01, 2005 |
|
EDITORIAL REVIEWS |
Product Description
This digital document is a journal article from Comparative Biochemistry and Physiology, Part C, published by Elsevier in 2005. The article is delivered in HTML format and is available in your Amazon.com Media Library immediately after purchase. You can view it with any web browser.Description: We investigated the transduction pathway mediated by Zn and 17@b-estradiol in isolated mantle/gonad cells of the mussel Mytilus galloprovincialis. Both the essential metal Zn, and the estrogen 17@b-estradiol, caused an increase in intracellular pH (pHi) of isolated mantle/gonad cells of the mussel M. galloprovincialis, thus indicating the activation of the Na^+/H^+ exchanger (NHE). The observed effect was inhibited by EIPA (20 nM), a specific NHE inhibitor, thus verifying NHE activation. Protein kinase C (PKC) also seemed to play an activating role in zinc and 17@b-estradiol effects on NHE and PK activity. In addition, the glycolytic enzyme pyruvate kinase (PK) was increased after zinc, while it was decreased after 17@b-estradiol treatment. It is noteworthy that, both the latter effects were reversed in the presence of EIPA, indicating the involvement of NHE in the signaling mechanism. cAMP seems to participate in the signaling mechanism induced by Zn but not to that induced by 17@b-estradiol. The potential implication of the heavy metal and 17@b-estradiol on the reproductive activity of the marine animals is discussed. |
|
![Zinc and 17@b-estradiol induce modifications in Na^+/H^+ exchanger and pyruvate kinase activity through protein kinase C in isolated mantle/gonad cells ... Biochemistry and Physiology, Part C]](http://ecx.images-amazon.com/images/I/51A51TBEEML._SL160_.jpg)
