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Detection of boldenone and its major metabolites by liquid chromatography-tandem mass spectrometry in urine samples [An article from: Analytica Chimica Acta] | Digital

by F. Buiarelli (Author), G.P. Cartoni (Author), F. Coccioli (Author), Giannetti (Author)

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Digital

Publisher:

Elsevier

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Product Description
This digital document is a journal article from Analytica Chimica Acta, published by Elsevier in . The article is delivered in HTML format and is available in your Amazon.com Media Library immediately after purchase. You can view it with any web browser.Description: Boldenone is an androgenic anabolic steroid (AAS) intensively used for growth promoting purposes in animals destined for meat production and as a performance enhancer in athletics. Therefore its use is officially banned either in animals intended for consumption or in humans. Because most anabolic steroids are completely metabolized and usually no parent steroid is excreted, metabolite identification is crucial to detect the illegal use of anabolic steroids either in humans or in livestock. The aim of this work is the investigation of 17@b-boldenone and its main metabolites, 17@b-sulphate, 17@b-glucuronide, 5@b-androst-1-en-17@b-ol-3-one and 17@a-boldenone, in human and bovine urine developing a multiresidue analysis. After solid phase extraction of urine samples, detection is carried out by high performance liquid chromatography-tandem mass spectrometry in multiple reaction monitoring. The average recovery for all the investigated compounds is above 70%. The developed method is very easy, quick and highly specific. Linearity, precision, decision limit and detection capability were also evaluated.