| View Larger Image | Di(2-ethylhexyl)phthalate (DEHP) exposure of voluntary plasma and platelet donors [An article from: International Journal of Hygiene and Environmental Health] | Digitalby H.M. Koch (Author), J. Angerer (Author), H. Drexler (Author), R. Eckstein (Author), We (Author)
| List Price: | $8.95 | | | Available: | Available for download now |
| | Binding: | Digital | | Publisher: | Elsevier |
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This digital document is a journal article from International Journal of Hygiene and Environmental Health, published by Elsevier in . The article is delivered in HTML format and is available in your Amazon.com Media Library immediately after purchase. You can view it with any web browser.Description: Each year thousands of healthy volunteers undergo apheresis procedures to donate blood components and safe lives. However, many disposables used in apheresis contain di(2-ethylhexyl)phthalate (DEHP). This way, donors are exposed to DEHP, which is a reproductive and developmental toxicant in animals and a suspected endocrine modulator in humans. We quantified the DEHP exposure of six plasma donors, six discontinuous-flow platelet donors and six continuous-flow platelet donors by determining three specific metabolites in urine (5OH-MEHP: mono(2-ethyl-5-hydroxyhexyl)phthalate; 5oxo-MEHP: mono(2-ethyl-5-oxo-hexyl)phthalate and MEHP: mono(2-ethylhexyl)phthalate). We found maximum concentrations in urine samples after the discontinuous-flow plateletpheresis procedure with 826@mg/l for 5OH-MEHP, 774@mg/l for 5oxo-MEHP and 266@mg/l for MEHP (mean of the six volunteers). Metabolite excretions were found to be significantly (p |
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