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Glucocorticoid-induced impairment of long-term memory retrieval in rats: An interaction with dopamine D2 receptors [An article from: Neurobiology of Learning and Memory] | Digital

by R. Pakdel (Author), A. Rashidy-Pour (Author)

List Price:

$7.95

Available:

Available for download now

Binding:

Digital

Publisher:

Elsevier

Page Count:

6 Pages

Publication Date:

May 01, 2006

EDITORIAL REVIEWS

Product Description
This digital document is a journal article from Neurobiology of Learning and Memory, published by Elsevier in 2006. The article is delivered in HTML format and is available in your Amazon.com Media Library immediately after purchase. You can view it with any web browser.Description: This study investigated glucocorticoid-dopaminergic interactions in modulating retrieval of long-term memory in an inhibitory avoidance task. Young adult male rats were trained in one trial inhibitory avoidance task (0.5mA, 3s footshock). On the retention test given 48h after training, the latency to re-enter the dark compartment of the apparatus was recorded. Systemically administered corticosterone (1 or 3mg/kg) given to rats 30min before retention testing impaired their memory retrieval, but the lower dose was more effective than the higher one. Administration of the dopamine (DA) D2 receptor antagonist sulpiride (6 or 20mg/kg) 30min before corticosterone attenuated the impairing effects of corticosterone (1mg/kg) on memory retrieval. Administration of the DA D1 receptor antagonist SCH23390 (25 or 50@mg/kg) had no effect on corticosterone-induced impairment of memory retrieval. Further, applied doses of sulpiride or SCH23390 alone were ineffective in modulating memory retrieval. These findings provide evidence for the existence of an interaction between glucocorticoids and DA D2 receptor on memory retrieval process.