| View Larger Image | Antiplatelet property of Curcuma longa L. rhizome-derived ar-turmerone [An article from: Bioresource Technology] | Digitalby H.S. Lee (Author)
| List Price: | $10.95 | | | Available: | Available for download now |
| | Binding: | Digital | | Publisher: | Elsevier | | Page Count: | 4 Pages | | Publication Date: | August 01, 2006 |
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Product Description
This digital document is a journal article from Bioresource Technology, published by Elsevier in 2006. The article is delivered in HTML format and is available in your Amazon.com Media Library immediately after purchase. You can view it with any web browser.Description: The antiplatelet activities of Curcuma longa L. rhizome-derived materials were measured using a platelet aggregometer and compared with those of aspirin as antiplatelet agent. The active constituent from the rhizome of Curcuma longa L. was isolated and characterized as ar-turmerone by various spectral analyses. At 50% inhibitory concentration (IC"5"0) value, ar-turmerone was effective in inhibiting platelet aggregation induced by collagen (IC"5"0, 14.4@mM) and arachidonic acid (IC"5"0, 43.6@mM). However, ar-turmerone had no effect on platelet activating factor or thrombin induced platelet aggregation. In comparison, ar-turmerone was significantly more potent platelet inhibitor than aspirin against platelet aggregation induced by collagen. These results suggested that ar-turmerone could be useful as a lead compound for inhibiting platelet aggregation induced by collagen and arachidonic acid. |
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