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Hopes of a New Treatment Approach for Paralysis
March 15, 2004Scientists at the Deutsches Krebsforschungszentrum (German Cancer Research Center, Heidelberg) were recently able to show in experiments with mice that a paralysis can be reversed by blocking programmed cell death.
Paralysis in the form of paraplegia and quadriplegia is usually the result of traumatic spinal cord injuries, but can also be caused by tumors. When the spinal cord is cut off, information sent by the brain can no longer be transmitted to the limbs. Biological processes such as programmed cell death, or apoptosis, take place after the actual moment of injury of the nerve cords and lead to further destruction of the damaged tissue and thus to permanent paralysis.
Dr. Ana Martin-Villalba and collaborators at the Immunogenetics Division headed by Professor Dr. Peter Krammer describe in the latest issue of the science journal Na-ture Medicine* how blockage of a key molecule of apoptosis restores the ability of coordinated movement of paralyzed limbs. Using specific antibodies, the investiga-tors blocked a protein called CD95 L which triggers a suicide cascade in cells carry-ing the specific receptor protein CD95.
The experiments showed that mice treated with antibodies after selective spinal cord injuries performed significantly better in special skill tests than the control animals. In addition, tissue sections of the treated animals revealed newly growing nerve fibers beyond the place of injury. Treatment with antibodies also prevented oligodendro-cytes from dying - cells that insulate the cord-like nerve fibers and thus facilitate sig-nal transmission.
Brain injuries and spinal cord injuries are the leading causes of deaths and severe disabilities in individuals under 40 years of age. In the future, specific blockage of apoptosis may become a way of preventing life-long paralysis by protecting injured nerves from further destruction.
*Deana Demjen, Stefan Klussmann et al.: Neutralization of CD95 ligand promotes regeneration and functional recovery after spinal cord injury. Nature Medicine, April 2004
Deutsches Krebsforschungszentrum
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