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Inflammatory bowel disease is a risk factor for thrombosis
March 09, 2004People with inflammatory bowel disease (IBD) are more than three times as likely to develop blood clots in their veins (venous thromboembolism), finds new research in Gut.
Thromboembolism is a serious and potentially life threatening event. For many years, patients with IBD were thought to be at increased risk, but the evidence has been inconsistent.
Furthermore, it is not known if this risk is specific for IBD or if it is shared by other chronic inflammatory diseases or bowel disorders, such as rheumatoid arthritis or coeliac disease.
Researchers surveyed 618 patients with IBD, 243 with rheumatoid arthritis, 207 with coeliac disease. All three patient groups were compared with matched control patients.
A total of 38 IBD patients (6.2%) suffered thromboembolism. This was significantly higher than the matched control group with only 10 cases reported (1.6%). The risk of thromboembolism was no higher in patients with rheumatoid arthritis or coeliac disease compared with controls.
IBD is a risk factor for thromboembolism, say the authors. It seems that thromboembolism is a specific feature of IBD as neither rheumatoid arthritis, nor coeliac disease had an increased risk. However, there appears to be no obvious explanation for these findings.
British Medical Journal (BMJ)
Researchers surveyed 618 patients with IBD, 243 with rheumatoid arthritis, 207 with coeliac disease. All three patient groups were compared with matched control patients.
A total of 38 IBD patients (6.2%) suffered thromboembolism. This was significantly higher than the matched control group with only 10 cases reported (1.6%). The risk of thromboembolism was no higher in patients with rheumatoid arthritis or coeliac disease compared with controls.
IBD is a risk factor for thromboembolism, say the authors. It seems that thromboembolism is a specific feature of IBD as neither rheumatoid arthritis, nor coeliac disease had an increased risk. However, there appears to be no obvious explanation for these findings.
British Medical Journal (BMJ)
Arthritis Current Events and Arthritis News RSSCan EP4 agonist alleviate gastric lesions?
Over 300 million patients use non-steroidal anti-inflammatory drugs (NSAIDs) in the world to treat pain, arthritis, fever and other diseases. Nearly 30% of the users suffer from gastric lesions and bleeding.
Thoughtful words help couples stay fighting fit
Couples who bring thoughtful words to a fight release lower amounts of stress-related proteins, suggesting that rational communication between partners can ease the impact of marital conflict on the immune system.
Penn Study Provides First Clear Idea of How Rare Bone Disease Progresses
An international team of scientists, led by researchers at the University of Pennsylvania School of Medicine, is taking the first step in developing a treatment for a rare genetic disorder called fibrodysplasia ossificans progressiva (FOP), in which the body's skeletal muscles and soft connective tissue turns to bone, immobilizing patients over a lifetime with a second skeleton.
Aileron collaborates study in Nature: Stapled peptides inhibit Notch1 transcription factor
This research validates the potential for Stapled Peptides to modulate key intracellular biological targets, such as transcription factors, that have not been addressable with current small molecule or biologic drug modalities.
Researchers find new way to attack inflammation in Graves' eye disease
A small group of patients with severe Graves' eye disease experienced rapid improvement of their symptoms - and improved vision - following treatment with the drug rituximab.
Common Pain Relievers May Dilute Power of Flu Shots
With flu vaccination season in full swing, research from the University of Rochester Medical Center cautions that use of many common pain killers - Advil, Tylenol, aspirin - at the time of injection may blunt the effect of the shot and have a negative effect on the immune system.
Mending meniscals in children, improving diagnosis and recovery
The meniscus is a rubber-like, crescent moon-shaped cartilage cushion that sits between the leg and thigh bone. Each knee has two menisci: one on the inside of the knee joint and one on the outside.
Study finds link between childhood physical abuse and arthritis
Adults who had experienced physical abuse as children have 56 per cent higher odds of osteoarthritis compared to those who have not been abused, according to a new study by University of Toronto researchers.
Pain thresholds linked to inflammation and sleep problems in arthritis patients
Despite recent advances in anti-inflammatory therapy, many rheumatoid arthritis (RA) patients continue to suffer from pain.
URI research couple's method targets cancerous tumors
Two University of Rhode Island associate professors, biophysicists Yana Reshetnyak and Oleg Andreev, have discovered a technology that can detect cancerous tumors and deliver treatment to them without the harming the healthy cells surrounding them, thereby significantly reducing side effects.
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