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New Way To Predict The Spread Of Skin Cancer
February 10, 2004A new way of predicting whether skin cancers will spread to other organs is published this week in the British Journal of Cancer. This means that resources can be concentrated on those patients most in need of close follow up, and lead to earlier detection of the cancer spreading.
Malignant melanomas result in 1,600 deaths a year in the UK due to the spread of the disease to other parts of the body. By measuring the density of lymph vessels surrounding a melanoma, scientists at Bristol University working with doctors at Frenchay Hospital in Bristol, have been able to predict which tumours will spread.
Previously, the best way of predicting whether a melanoma was likely to spread was by measuring its thickness, since it was believed that the thicker a tumour was, the more likely it was to spread. But many thin melanomas spread and only 40% of thick ones do.
The team looked for, and found, a far more reliable method of prediction than thickness. They looked at the density of lymph vessels around melanomas stored at Frenchay Hospital and saw which patients actually went on to develop secondary cancers within 8 years. They used this information to develop a better prediction for the spread of the cancers.
Dr David Bates, scientific director of the Microvascular Research Laboratories at Bristol University said: 'We shall now be looking at a larger study of many hundreds of patients. If our findings are confirmed it will mean that the likelihood of a patient developing cancer in other organs could be predicted ahead of time with reasonable certainty. Resources can then be concentrated on those patients most in need of close follow up, and hopefully lead to earlier detection of the spread of cancer.'
Bristol, University of
The team looked for, and found, a far more reliable method of prediction than thickness. They looked at the density of lymph vessels around melanomas stored at Frenchay Hospital and saw which patients actually went on to develop secondary cancers within 8 years. They used this information to develop a better prediction for the spread of the cancers.
Dr David Bates, scientific director of the Microvascular Research Laboratories at Bristol University said: 'We shall now be looking at a larger study of many hundreds of patients. If our findings are confirmed it will mean that the likelihood of a patient developing cancer in other organs could be predicted ahead of time with reasonable certainty. Resources can then be concentrated on those patients most in need of close follow up, and hopefully lead to earlier detection of the spread of cancer.'
Bristol, University of
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Hundreds of genes distinguish patients likely to survive advanced melanoma
Although the chances of surviving advanced melanoma aren't very good with current therapies, some patients can live for years with cancer that has spread beyond the skin to other organs.
New Notre Dame study provides insights into the molecular basis of tumor cell behavior
A new study by a team of researchers led by Crislyn D'Souza-Schorey, associate professor of biological sciences at the University of Notre Dame, sheds light on the molecular basis by which tumor cells modulate their surroundings to favor cancer progression.
Switching immunosuppressants reduces cancer risk in kidney
Switching to a newer type of immunosuppressant drug may reduce the high rate of skin cancer after kidney transplantation, according to research being presented at the American Society of Nephrology's 42nd Annual Meeting and Scientific Exposition in San Diego, CA.
Cancer survivors may not be getting the help they need to stop smoking
More than a quarter of cancer survivors who still smoke have not been advised to quit smoking by their health care providers in the last year, according to a study published by researchers at Fox Chase Cancer Center in the current issue of the Journal of General Internal Medicine.
Melanoma treatment options 1 step closer
A targeted chemotherapy for the treatment of skin cancer is one step closer, after a team of University of Alberta researchers successfully synthesized a natural substance that shows exceptional potential to specifically treat this often fatal disease.
Resident physicians seldom trained in skin cancer examination
Many resident physicians are not trained in skin cancer examinations, nor have they ever observed or practiced the procedure.
New findings on the formation of body pigment
The skin's pigment cells can be formed from completely different cells than has hitherto been thought, a new study from the Swedish medical university Karolinska Institutet shows. The results, which are published in the journal Cell, also mean the discovery of a new kind of stem cell.
Studying cancer in pet dogs to find new treatments for human patients
A team of scientists at the National Cancer Institute (NCI) in Bethesda, USA, says that studying pet dogs with cancer could yield valuable information on how to diagnose and treat human cancers.
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