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Boehringer Ingelheim enters into multi-target drug discovery collaboration with Morphochem.
February 04, 2004Morphochem AG, a leader in the evolutionary discovery of small molecule drugs announced that it has entered into a research collaboration with Boehringer Ingelheim, a leading pharmaceutical company with a focus on human pharmaceuticals and animal health. Morphochem will apply its drug discovery engine MOREsystem™ to the discovery and optimization of novel structures with activity against several undisclosed novel human targets.
Financial terms of the collaboration were not disclosed.
MOREsystem™ combines multi-component reaction chemistry (MCR) with Morphochem's proprietary software MolMind™ that is based on genetic algorithms using in-silico and biological feedback. This drug discovery engine generates a range of target-directed virtual small compound libraries for hit and lead discovery in parallel, from which suitable compounds will be chosen for synthesis and biological testing. This approach reduces the attrition rate for drug candidates and allows patents to be filed early for novel compounds. Initial in-silico model building will be facilitated by Morphochem's novel proprietary 3D shape similarity tool AutoPhore®. This will enable rapid access to bioisosteric solutions, scaffold hopping and provide a realistic estimate of the probability of the projects success.
Dr Peter Seufer-Wasserthal VP Business Development at Morphochem commented:
"We are very pleased to collaborate with Boehringer Ingelheim and to contribute towards their drug discovery and development programs. This collaboration endorses the value of our novel approach. Compounds can be checked for fit with a target and then further refined using evolutionary algorithms so that potential drug candidates can be pre-optimized for biological activity and drug potential before synthesis is started."
Northbank Communications
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