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Doubling of steroids before severe asthma attacks ineffective (p 271)
January 21, 2004Recommendations to double inhaled steroids at the start of asthma attacks are challenged by research findings in this week's issue of THE LANCET.
Doubling the dose of inhaled corticosteroid when asthma control deteriorates is widely advocated but is of unproven value. Tim Harrison from the department of respiratory medicine, Nottingham City Hospital, UK, and colleagues studied 390 asthma patients, deemed to be at risk of an asthma exacerbation. Patients monitored their asthma for up to one year and were instructed to add an extra inhaler (either steroid or placebo) for two weeks when their asthma control deteriorated.
There was no statistically significant difference in the proportion of people requiring oral steroids (the main study outcome) between the active and placebo groups (around 12% of patients in both groups).
Tim Harrison comments: "Our findings provide little support for the recommendation that patients taking an inhaled corticosteroid should double the dose when asthma control is deteriorating. Whether a larger increase in inhaled corticosteroid dose would be effective needs to be established. Until more data are available patients should continue to take a short course of oral steroids for asthma exacerbations"
Lancet
Tim Harrison comments: "Our findings provide little support for the recommendation that patients taking an inhaled corticosteroid should double the dose when asthma control is deteriorating. Whether a larger increase in inhaled corticosteroid dose would be effective needs to be established. Until more data are available patients should continue to take a short course of oral steroids for asthma exacerbations"
Lancet
Asthma Current Events and Asthma News RSSExposures to metals and diesel emissions in air linked to respiratory symptoms in children
Exposure shortly after birth to ambient metals from residential heating oil combustion and particles from diesel emissions are associated with respiratory symptoms in young inner city children.
Exposure to both traffic, indoor pollutants puts some kids at higher risk for asthma later
New research presents strong evidence that the "synergistic" effect of early-life exposure to both outdoor traffic-related pollution and indoor endotoxin causes more harm to developing lungs than one or the other exposure alone.
Johns Hopkins researchers track down protein responsible for chronic rhinosinusitis with polyps
A protein known to stimulate blood vessel growth has now been found to be responsible for the cell overgrowth in the development of polyps that characterize one of the most severe forms of sinusitis, a study by Johns Hopkins researchers suggests.
Ancestry attracts, but love is blind
People preferentially marry those with similar ancestry, but their decisions are not necessarily based on hair, eye or skin colour.
Common plastics chemicals linked to ADHD symptoms
Phthalates are important components of many consumer products, including toys, cleaning materials, plastics, and personal care items.
Asthma a significant risk factor for complications in children with H1N1
A new study on pediatric H1N1 influenza admissions has found that asthma is a significant risk factor for severe disease in children with pandemic H1N1 compared with the seasonal flu.
Mother's Depression a Risk Factor in Childhood Asthma Symptoms, Study Suggests
Asthma symptoms can worsen in children with depressed mothers, according to research from Johns Hopkins Children's Center published online in the Journal of Pediatric Psychology.
Sweet -- sugared polymer a new weapon against allergies and asthma
Scientists at Johns Hopkins and their colleagues have developed sugar-coated polymer strands that selectively kill off cells involved in triggering aggressive allergy and asthma attacks.
Pivotal study for PSD502 -- the first potential treatment for premature ejaculation
At the annual meeting of the Sexual Medicine Society of North America (SMSNA), Inc. in San Diego, Sciele Pharma, Inc., a Shionogi Company and Plethora Solutions Limited, a wholly owned subsidiary of Plethora Solutions Holdings PLC ("Plethora" - AIM:PLE)., today presented data from its second positive pivotal study of PSD502 for the treatment of premature ejaculation (PE).
Aileron collaborates study in Nature: Stapled peptides inhibit Notch1 transcription factor
This research validates the potential for Stapled Peptides to modulate key intracellular biological targets, such as transcription factors, that have not been addressable with current small molecule or biologic drug modalities.
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