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Vernalis plc: Research and Development Update

November 27, 2003

Vernalis plc (LSE: VER, NASDAQ: VNLS) is today providing to sector analysts a comprehensive update on in its R&D pipeline. Highlights include:

Frovatriptan
A Phase III long-term safety study has been initiated to support the extension of frovatriptan's approved use to the prevention of menstrually-associated migraine. A confirmatory Phase III efficacy study will also begin in Q1 2004, with US and EU regulatory submissions planned in 2005.

BB-10153
This novel recombinant thrombolytic protein, targeted at stroke, has been assessed in an initial Phase II proof-of-concept ascending dose study in acute myocardial infarction (AMI), in 28 patients. The product met its initial efficacy end point, with full coronary blood flow restored in three out of seven patients at the 5mg/kg dose. Its safety profile was encouraging, with no bleeding observed. It is now being assessed in up to 35 further patients, with FDA approval to evaluate it up to a 10mg/kg dose.

5HT2C receptor agonists
Roche has now selected a development candidate from this collaborative research programme for obesity, to progress into pre-clinical studies. Upon successful completion of pre-clinical testing, clinical studies will also be undertaken by Roche.

R140
This GABAA agonist for the treatment of pain in cancer patients is being assessed in a Phase I clinical programme. Multiple doses were well tolerated, with no obvious signs of sedation. Phase IIa studies are planned to begin during 2004.

VR-2006
This adenosine A2A receptor antagonist, a potential new treatment for Parkinson's disease, has begun Phase I clinical studies.

Vernalis' Chief Executive Officer, Simon Sturge, said: "At the beginning of October we announced that Vernalis would focus on its most competitive R&D pipeline products. Today's announcement shows advances in all these key areas."

Northbank Communications

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