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Zeroing in on Alzheimer's
September 25, 2003Hereditary Alzheimer's disease has been shown to be the result of mutations in certain specific genes. Other cases of Alzheimer's are also assumed to be traceable to the influence of a number of still unidentified genes. It is probable that these genes are located in a large area on chromosome 10q, which contains more than 100 genes.
Working with researchers in Gothenburg and Los Angeles, scientists at the Karolinska Institute in Stockholm, Sweden have now narrowed down the area of interest on chromosome 10 to include only three genes. The results are being published in the journal Human Mutation Online, September 24, 2003.
One of these highly interesting genes codes for the protein insulin degrading enzyme (IDE). This protein is a strong candidate for a role in Alzheimer's owing to its biological function -- it breaks down extracellular amyloid-beta protein, one of the substances that make up the senile plaque that is formed in Alzheimer's.
The study has analyzed the DNA from 648 patients with Alzheimer's and 663 healthy individuals. The results show a significant coupling between the limited three-gene region including the gene for IDE and the risk of disease and the severity of the disease.
Vetenskapsrådet (The Swedish Research Council)
Alzheimer Disease Current Events and Alzheimer Disease News RSSVitamin B does not slow cognitive decline in Alzheimer's
A clinical trial led by Paul S. Aisen, M.D., professor of neurosciences at the University of California, San Diego School of Medicine, showed that high-dose vitamin B supplements did not slow the rate of cognitive decline in patients with mild to moderate Alzheimer disease.
Protecting patient privacy the new fashioned way
Protecting patient privacy has been recognized as the duty of health-care providers for about as long as doctors have seen patients. In 1996 that duty became a legal obligation when Congress passed the Health Insurance Portability and Accountability Act.
Study confirms benefit of combination therapy for Alzheimer's disease
Extended treatment with Alzheimer's disease drugs can significantly slow the rate at which the disorder advances, and combination therapy with two different classes of drugs is even better at helping patients maintain their ability to perform daily activities.
Seniors with type 2 diabetes may experience memory declines immediately after eating unhealthy meal
Adults with type 2 diabetes who eat unhealthy, high-fat meals may experience memory declines immediately afterward, but this can be offset by taking antioxidant vitamins with the meal, according to new research from Baycrest.
Memory loss linked to common sleep disorder
For the first time, UCLA researchers have discovered that people with sleep apnea show tissue loss in brain regions that help store memory.
Strong associations between disturbed rest/activity rhythms and mortality rates in older men
A research abstract that will be presented on Wednesday at SLEEP 2008, the 22nd Annual Meeting of the Associated Professional Sleep Societies (APSS), is the first to report strong associations between disturbed rest/activity rhythms and mortality rates in older, community-dwelling (non-institutionalized) men.
Hopkins researchers discover new link to schizophrenia
Neuroscientists at Johns Hopkins have discovered that mice lacking an enzyme that contributes to Alzheimer disease exhibit a number of schizophrenia-like behaviors.
A significant difference in the sleep disturbances among Alzheimer patients, caregivers
A study published in the May 1 issue of the journal SLEEP finds that sleep disturbances among Alzheimer patients vary significantly from those of their family caregivers, and that, surprisingly, poor sleep in either the patient or caregiver is not necessarily linked to disturbed sleep in the other.
Alzheimer's vaccine clears plaque but has little effect on learning and memory impairment
A promising vaccine being tested for Alzheimer's disease does what it is designed to do - clear beta-amyloid plaques from the brain - but it does not seem to help restore lost learning and memory abilities, according to a University of California, Irvine study.
Why fish oil is good for you
It's good news that we are living longer, but bad news that the longer we live, the better our odds of developing late-onset Alzheimer's disease.
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