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If You Are Down, You May Be More Likely To Get Infections
September 01, 2003The association between depression and immune response is not yet clear. The biological mechanisms by which depression alters the immune system is not yet understood. The purpose of this study was to investigate the longitudinal relationship between depressive symptoms and cellular immune response.
A cohort study with a baseline measurement and three annual health assessments was set up in a residential home for elderly people in Rome, Italy. A total of 166 residents aged 65 years and older, mean age 81 years, were interviewed and blood samples were collected at each annual assessment.
Percentage changes in lymphocytes and T-cell subsets related to depressive symptoms were estimated over a period of 4 years, using regression models for repeated measurements. Elderly people with seven or more symptoms of depression, according to the Geriatric Depression Scale, had a lower percentage of CD4+DR+ T-cells over 4 years [ = -20.2; 95% confidence interval (CI) = -33.0 to -4.9] and CD8+DR+ T-cells ( = -26.9; 95% CI = -42.5 to -7.0) than elderly with less than seven symptoms of depression, after adjusting for confounding factors (sex, age, marital status, education, smoking habit, nutritional status, chronic diseases, disability and the use of benzodiazepines).
The results of this study suggest an adverse effect of depressive symptoms on immune response. It remains to be determined whether these depression-associated immune changes are related to the onset or course of physical illness and the increased mortality observed in depressed old people.
Psychotherapy and Psychosomatics, Journal of
Depression Current Events and Depression News RSSDepression rife among medical students
Medical students frequently suffer from depression, especially during their internship years. New research published in the open access journal BMC Medical Education reveals the extent of the problem and features a detailed analysis of the symptoms and sufferers.
Happiness is infectious
Happiness really does rub off—a person's happiness depends on the happiness of others with whom they are connected, finds research published on bmj.com today.
Study strengthens link between tobacco smoke and behavioral problems in boys with asthma
Boys with asthma who are exposed to environmental tobacco smoke have higher degrees of hyperactivity, aggression, depression and other behavioral problems, according to researchers at Cincinnati Children's Hospital Medical Center.
Nearly 5 percent of the US population suffers from persistent depression or anxiety
Though effective treatments are available for individuals suffering from chronic depression and anxiety, very little is known about how often these treatments are used or how prevalent these conditions are among the nation's general population.
Too much commitment may be unhealthy for relationships, UH psychology professor says
Romantic relationships establish special bonds between partners. Oftentimes, passionate rapport leads to permanent partnerships, and ultimately, the start of families.
Stress-related disorders affect brain's processing of memory
Researchers using functional MRI (fMRI) have determined that the circuitry in the area of the brain responsible for suppressing memory is dysfunctional in patients suffering from stress-related psychiatric disorders. Results of the study will be presented today at the annual meeting of the Radiological Society of North America (RSNA).
Gay men's risky sexual behavior linked to feeling undesirable
Gay men who are not considered sexually desirable are more likely to engage in risky sexual behavior according to new research out of the University of Toronto. They may also develop psychological problems as a consequence of feeling undesirable.
Lower childhood IQ associated with higher risk of adult mental disorders
Researchers have hypothesized that people with lower IQs may have a higher risk of adult mental disorders, but few studies have looked at the relationship between low childhood IQ and psychiatric disorders later in life.
Exercise helps overweight children reduce anger expression
Regular exercise seems to reduce anger expression in overweight but otherwise healthy children, researchers said.
Bipolar disorder genes, pathways identified by Indiana University neuroscientists
Neuroscientists at the Indiana University School of Medicine have created the first comprehensive map of genes likely to be involved in bipolar disorder.
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