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Bisphosphonate drugs reduce the risk of broken bones in breast cancer patients
August 29, 2003Bisphosphonate drugs reduce the risk of bone complications when used in patients whose cancer has spread to the bone, according to a new study in the BMJ.
Researchers reviewed over 30 studies examining the effect of bisphosphonates - a group of drugs commonly used to treat osteoporosis - on complications of secondary bone cancer. Cancers that commonly spread to the bone include breast cancer, prostate cancer and multiple myeloma.
They found that patients given bisphosphonate drugs were much less likely to suffer from fractures, or need orthopaedic surgery or radiotherapy. The researchers also found that patients given bisphosphonate drugs remained free of bone complications for a significantly longer period of time compared to those who did not receive the drug. However, patients given bisphosphonates did not survive longer.
The authors conclude that these drugs should be given to patients as soon as spread of cancer to the bone is diagnosed. They also report that most of the available evidence supports the use of amino-bisphosphonates, given intravenously.
British Medical Journal (BMJ)
The authors conclude that these drugs should be given to patients as soon as spread of cancer to the bone is diagnosed. They also report that most of the available evidence supports the use of amino-bisphosphonates, given intravenously.
British Medical Journal (BMJ)
Cancer News and Current Cancer Events RSSNew insights into the regulation of PTEN tumor suppression function
The PTEN tumor suppressor gene controls numerous biological processes including cell proliferation, cell growth and death. But PTEN is frequently lost or mutated; in fact, alteration of the gene is so common among various types of human cancer that PTEN has become one of the most frequently mutated of all tumor suppressors.
Researchers discover how rheumatoid arthritis causes bone loss
Researchers have discovered key details of how rheumatoid arthritis (RA) destroys bone, according to a study published in the Aug. 22 edition of the Journal of Biological Chemistry.
Making 'good' fat from muscle and vice versa
A surprise discovery -- that calorie-burning brown fat can be produced experimentally from muscle precursor cells in mice -- raises the prospect of new ways to fight obesity and overweight, say scientists from Dana-Farber Cancer Institute.
Researchers discover scent of skin cancer
According to new research from the Monell Center, odors from skin can be used to identify basal cell carcinoma, the most common form of skin cancer. The findings, presented at the 236th meeting of the American Chemical Society, may open doors to development of new methods to detect basal cell carcinoma and other forms of skin cancer.
Cervical cancer prevention should focus on vaccinating adolescent girls
The cost-effectiveness of vaccination in the United States against human papillomavirus (HPV), a sexually-transmitted virus that causes cervical cancer, will be optimized by achieving universal vaccine coverage in young adolescent girls, by targeting initial "catch-up" efforts to vaccinate women younger than 21 years of age, and by revising current screening policies.
Obesity raises risks of serious digestive health concerns
The prevalence of obesity and overweight in the United States coupled by the increased risk of gastrointestinal diseases related to obesity raises serious implications for the health of Americans.
Bowel cancer indicator should lead to better treatment
STEM cell scientists have developed a more accurate way of identifying aggressive forms of bowel cancer, which should eventually lead to better treatment and survival rates.
Stem cell indicator for bowel cancer should lead to better survival rates
Stem cell scientists have developed a more accurate way of identifying aggressive forms of bowel cancer, which should eventually lead to better treatment and survival rates. Bowel cancer is the third most common cancer in the UK.
Infection Blocks Lung's Protective Response Against Tobacco Smoke
An infection that often goes undetected can block the lung's natural protective response against tobacco smoke, according to researchers at National Jewish Health.
NYU scientists identify critical protein complex in formation of cell cilia
An international team led by NYU Cancer Institute have identified a protein complex that regulates the formation of cilia, which are found on virtually all mature human cells and are essential to normal cell function.
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