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Cancer Research UK supports additional TroVax phase II trial in colorectal cancer
August 28, 2003Oxford BioMedica announced today that Cancer Research UK (CRUK) has agreed to conduct and sponsor an open label Phase II trial with Oxford BioMedica's leading cancer immunotherapy product, TroVax®, in colorectal cancer patients who have liver metastases. The decision by CRUK follows extensive review of the successful Phase I/II data of TroVax in colorectal cancer patients. This study is in addition to the two ongoing Phase II trials with TroVax in colorectal cancer alongside chemotherapy, and the planned trials in renal and breast cancer.
The patient population in the CRUK Phase II trial will comprise twenty Stage IV colorectal cancer patients who are to undergo surgery for resectable liver metastases. Patients will receive injections of TroVax followed by surgery approximately two weeks later. Biopsies of the tumour will be taken at surgery and analysed for TroVax stimulated immune activity. Further vaccinations will be given after surgery. Patients' management will then continue as standard, usually including adjuvant chemotherapy. Patients will be followed after the final vaccination to assess immune responses and toxicity and then monitored over the longer term for clinical benefit.
Commenting on the announcement, Oxford BioMedica's chief executive, Professor Alan Kingsman said, "Cancer Research UK is one of the world's leading cancer research organisations and is committed to the development of better cancer treatments for patients. Their involvement in this project provides further validation of Oxford BioMedica's advanced cancer immunotherapeutic."
Northbank Communications
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Screening for colorectal cancer detects unrecognized disease
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A new class of compounds called phosphaplatins can effectively kill ovarian, testicular, head and neck cancer cells with potentially less toxicity than conventional drugs, according to a new study published this week in the journal Proceedings of the National Academy of Sciences.
Survival of head and neck cancer patients is greatly affected by coexisting ailments
Current estimates for head and neck cancer survival are largely inaccurate because they widely disregard many of the most common diseases such patients have in addition to their primary cancer, says Jay Piccirillo, M.D., a head and neck specialist at Washington University School of Medicine in St. Louis, the Siteman Cancer Center and Barnes-Jewish Hospital.
Home-based diet and exercise intervention improves elderly cancer survivors' physical function
A home-based program to improve exercise and diet led to significant, clinically meaningful improvement in body weight and physical function among older long-term cancer survivors in preliminary findings from the RENEW (Reach-out to ENhancE Wellness) trial.
Adalimumab may reduce health-care costs for Crohn's disease patients
Inflammatory bowel disease (IBD) is a term that refers to both ulcerative colitis (UC) and Crohn's disease (CD). IBD occurs most frequently in people in their late teens and twenties. There have been cases in children as young as two years old and in older adults in their seventies and eighties; men and women have an equal chance of getting the disease.
SNPs affect folate metabolism in study of Puerto-Rican adults
Researchers at Tufts University have gained further understanding of the genomic basis for altered folate metabolism and the content of uracil in blood DNA.
National call for cancer clinical trial system to be more responsive to community needs
Addressing the nation's continuing poor performance in cancer clinical trial participation, particularly among racial and ethnic minorities and low income groups, will require meaningful public involvement in the design and implementation of clinical trials, according to a landmark report released today.
Surgical Removal of Small Colon Polyps is Costly and Unnecessary
Polypectomy (the surgical removal of polyps by colonoscopy) of small polyps found during CT colonography is costly and unnecessary according to a study performed at the University of Wisconsin School of Medicine and Public Health in Madison, WI.
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