Science Current Events | Science News | Brightsurf.com
 

New gene for familial high cholesterol

May 13, 2016

New research from Denmark reveals the gene that explains one quarter of all familial hypercholesterolemia with very high blood cholesterol. Familial hypercholesterolemia is the most common genetic disorder leading to premature death, found in 1 in 200 people.

A research group lead by Clinical Professor Borge G. Nordestgaard has found that cholesterol-containing lipoprotein(a) is the cause of one quarter of all diagnoses of familial hypercholesterolemia. High levels of this genetically determined lipoprotein in the blood is already known to cause heart attacks.

"Among 46,200 individuals in the general population, individuals with a diagnosis of familial hypercholesterolemia have higher levels of lipoprotein(a) in their blood than individuals without the diagnosis," says principal investigator Dr. Anne Langsted, Herlev Hospital, Copenhagen University Hospital, Denmark.

The research has just been published in The Lancet Diabetes & Endocrinology.

High risk of heart attack

The study also reveals that high levels of lipoprotein(a) in the blood adds to the already very high risk of suffering a heart attack for people with familial hypercholesterolemia. "We find that individuals with familial hypercholesterolemia and high levels of lipoprotein(a) are five times more likely to suffer a heart attack than individuals without these two conditions," adds Anne Langsted.

"Our results suggest that all individuals with familial hypercholesterolemia should have their lipoprotein(a) concentrations measured in order to identify those with the highest concentrations and therefore also the highest risk of suffering a heart attack," says senior author Borge G. Nordestgaard, University of Copenhagen and Copenhagen University Hospital.

"Worldwide, familial hypercholesterolemia as well as high lipoprotein(a) levels are grossly underdiagnosed and undertreated. Our findings will help identify the individuals with the highest risk of suffering a heart attack and hopefully facilitate better preventive treatment for these extremely high risk individuals," adds Nordestgaard.

The diagnosis of familial hypercholesterolemia is based on different clinical signs such as elevated cholesterol, relatives with early heart attack and a personal history of heart attack. Genetic testing can also confirm the diagnosis.

University of Copenhagen The Faculty of Health and Medical Sciences


Related Familial Hypercholesterolemia Current Events and Familial Hypercholesterolemia News Articles


Single-gene mutations account for only 2 percent of cases of severely elevated cholesterol
A study from an international research team finds that familial hypercholesterolemia (FH) - a genetic condition that causes greatly elevated levels of LDL cholesterol throughout life - accounts for less than 2 percent of severely elevated LDL in the general population.

Genes causing high cholesterol are less common than previously thought
Only a small fraction of people with very high cholesterol can attribute their condition to a genetic mutation related to familial hypercholesterolemia, but individuals with these mutations face a high risk of developing early-onset coronary artery disease, according to research presented at the American College of Cardiology's 65th Annual Scientific Session.

Urine-derived stem cells predict patient response to cholesterol-lowering drugs
We all know how important it is to keep our levels of blood cholesterol - especially the 'bad' variety - in check with a healthy diet and regular exercise.

Lower prevalence of diabetes found among patients with inherited high cholesterol disorder
The prevalence of type 2 diabetes among 25,000 patients with familial hypercholesterolemia (a genetic disorder characterized by high low-density lipoprotein [LDL] cholesterol levels) was significantly lower than among unaffected relatives, with the prevalence varying by the type of gene mutation.

Concerning number of kids have elevated cholesterol
Roughly one out of three kids screened for high cholesterol between the ages of 9 and 11 has borderline or high cholesterol, potentially placing them at greater risk for future cardiovascular disease, according to research to be presented at the American College of Cardiology's 63rd Annual Scientific Session.

Early statin therapy helps kids with inherited high cholesterol
Children with inherited high levels of cholesterol who receive cholesterol-lowering statins in their early years have a lower risk of coronary heart disease than their affected parents.

ALS trial shows novel therapy is safe
An investigational treatment for an inherited form of Lou Gehrig's disease has passed an early phase clinical trial for safety, researchers at Washington University School of Medicine in St. Louis and Massachusetts General Hospital report.

New medication shows promise as lipid-lowering therapy for rare cholesterol disorder
An international effort led by researchers at the Perelman School of Medicine at the University of Pennsylvania has resulted in positive phase 3 clinical trial results for a new medicine to treat patients suffering from a rare and deadly cholesterol disorder.

High blood cholesterol is overlooked
High blood cholesterol, a serious hereditary disease, is far more common than previously recognised and not treated sufficiently.

Finding the silent killer -- a biomarker test for atherosclerosis
Furring of the arteries, atherosclerosis, is a leading cause of death across the world. Atherosclerosis leads to peripheral arterial disease, coronary heart disease, stroke and heart attacks.
More Familial Hypercholesterolemia Current Events and Familial Hypercholesterolemia News Articles

Cholesterol and statins: Sham science and bad medicine

Cholesterol and statins: Sham science and bad medicine
by Thierry Souccar Publishnig


REVIEW
Dr. de Lorgeril, the architect of the famous secondary prevention trial of the Mediterranean Diet has written a game-changing book exposing the truth about cholesterol and statins. In short, his comprehensive assessment of pharmaceutical trials is the most meticulous dissection of statin clinical trials I have ever seen. This book is a must read for anyone with clinical heart disease or anyone vulnerable to heart disease including those with positive family histories, and especially in those considering statin therapy. Highly recommended!

--- Stephen T. Sinatra, M.D., F.A.C.C., F.A.C.N., Cardiologist and co-author of The Great Cholesterol Myth


With the 2013 US and UK guidelines on the prevention of cardiovascular disease, tens of millions of...

Dyslipidemias: Pathophysiology, Evaluation and Management (Contemporary Endocrinology)

Dyslipidemias: Pathophysiology, Evaluation and Management (Contemporary Endocrinology)
by Abhimanyu Garg (Editor)


Dyslipidemias: Pathophysiology, Evaluation and Management provides a wealth of general and detailed guidelines for the clinical evaluation and management of lipid disorders in adults and children. Covering the full range of common through rare lipid disorders, this timely resource offers targeted, practical information for all clinicians who care for patients with dyslipidemias, including general internists, pediatric and adult endocrinologists, pediatricians, lipidologists, cardiologists, internists, and geneticists. For the last twenty years, there has been a growing recognition worldwide of the importance of managing dyslipidemia for the primary and secondary prevention of atherosclerotic vascular disease, especially coronary heart disease. This has been mainly due to the publication...

Towards Genetic Prediction of Coronary Heart Disease in Familial Hypercholesterolemia

Towards Genetic Prediction of Coronary Heart Disease in Familial Hypercholesterolemia
by Jeroen Van Der Net (Author)




Complex Genetics of Monogenic Familial Hypercholesterolemia

Complex Genetics of Monogenic Familial Hypercholesterolemia
by K. C. M. C. Koeijvoets (Author)




  Genetics and Therapy of Familial Hypercholesterolemia
by P. R. W. de Sauvage Nolting (Author)




ACAT Inhibition and Progression of Carotid Atherosclerosis in Patients With Familial Hypercholesterolemia: The CAPTIVATE Randomized Trial / Religious Coping and Use of Intensive Life-Prolonging Care Near Death in Patients With Advanced Cancer (JAMA: The Journal of the American Mediacl Association, Volume 301, Number 11, March 18, 2009)

ACAT Inhibition and Progression of Carotid Atherosclerosis in Patients With Familial Hypercholesterolemia: The CAPTIVATE Randomized Trial / Religious Coping and Use of Intensive Life-Prolonging Care Near Death in Patients With Advanced Cancer (JAMA: The Journal of the American Mediacl Association, Volume 301, Number 11, March 18, 2009)
by M. C. Meuwese (Author)


ACAT Inhibition and Progression of Carotid Atherosclerosis in Patients With Familial Hypercholesterolemia: The CAPTIVATE Randomized Trial / Religious Coping and Use of Intensive Life-Prolonging Care Near Death in Patients With Advanced Cancer (JAMA: The Journal of the American Mediacl Association, Volume 301, Number 11, March 18, 2009)

Ignore the awkward! How the cholesterol myths are kept alive

Ignore the awkward! How the cholesterol myths are kept alive
by CreateSpace


The cholesterol campaign is the greatest medical scandal in modern time. If you have read the author's previous books ´The Cholesteol Myths´ (out of print) or 'Fat and Cholesterol are GOOD for You', you should know that for certain. For instance, according to more than 25 scientific studies old people with high cholesterol live the longest. Another shocking fact is that the authors of a recent American study of more than 130,000 patients with acute myocardial infarction found that on average, their cholesterol was lower than normally. Their finding has already been confirmed by others. What they also found was that three years later, mortality was twice as high among those whose cholesterol was the lowest. Their conclusion? We must lower cholesterol even more! But there is much, much...

Integrative Cardiovascular Chinese Medicine: A Prevention and Personalized Medicine Perspective

Integrative Cardiovascular Chinese Medicine: A Prevention and Personalized Medicine Perspective
by Academic Press


Combining the research and study of integrative Chinese and Western Medicine, Integrative Cardiovascular Chinese Medicine: A Prevention and Personalized Medicine Perspective presents a clear, structured base to guide clinical practice and encourage collaboration between Chinese medicine and Western medicine practitioners. This complete reference work thoroughly covers the pathophysiology of cardiology-related diseases, and compares, juxtaposes, and integrates Western and traditional Chinese medicine (TCM). Anika Niambi Al-Shura provides a realistic scope of cardiology treatment and the integration of Western and Chinese medicine, establishing a basis for standardization and a rationale for the inclusion of TCM in cardiology, and identifying and inspiring ideas for future...

Cardiovascular Diseases: Genetic Susceptibility, Environmental Factors and their Interaction

Cardiovascular Diseases: Genetic Susceptibility, Environmental Factors and their Interaction
by Nikolaos Papageorgiou (Author)


Cardiovascular Diseases: Genetic Susceptibility, Environmental Factors and Their Interaction covers the special heritability characteristics and identifying genetic and environmental contributions to cardiovascular health. This important reference provides an overview of the genetic basis of cardiovascular disease and its risk factors. Included are important topics, ranging from lifestyle choices, risk factors, and exposure, to pollutants and chemicals. Also covered are the influences of Mendelian traits and familial aggregation and the interactions and interrelationships between genetics and environmental factors which, when compared, provide a sound understanding of the interplay between inherited and acquired risk factors. The book provides a much needed reference for this rapidly...

© 2017 BrightSurf.com