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Review finds fathers' age, lifestyle associated with birth defects

May 16, 2016

WASHINGTON -- A growing body of research is revealing associations between birth defects and a father's age, alcohol use and environmental factors, say researchers at Georgetown University Medical Center. They say these defects result from epigenetic alterations that can potentially affect multiple generations.

The study, published in the American Journal of Stem Cells, suggest both parents contribute to the health status of their offspring -- a common sense conclusion which science is only now beginning to demonstrate, says the study's senior investigator, Joanna Kitlinska, PhD, an associate professor in biochemistry, and molecular and cellular biology.

"We know the nutritional, hormonal and psychological environment provided by the mother permanently alters organ structure, cellular response and gene expression in her offspring," she says.

"But our study shows the same thing to be true with fathers -- his lifestyle, and how old he is, can be reflected in molecules that control gene function," she says. "In this way, a father can affect not only his immediate offspring, but future generations as well."

For example, a newborn can be diagnosed with fetal alcohol spectrum disorder (FASD), even though the mother has never consumed alcohol, Kitlinska says. "Up to 75 percent of children with FASD have biological fathers who are alcoholics, suggesting that preconceptual paternal alcohol consumption negatively impacts their offspring."

The report is a review of evidence, human and animal, published to date on the link between fathers and heritable epigenetic programming.

Among the studies reviewed are ones that find:

- Advanced age of a father is correlated with elevated rates of schizophrenia, autism, and birth defects in his children;

- A limited diet during a father's pre-adolescence has been linked to reduced risk of cardiovascular death in his children and grandchildren;

- Paternal obesity is linked to enlarged fat cells, changes in metabolic regulation, diabetes, obesity and development of brain cancer;

- Psychosocial stress on the father is linked to defective behavioral traits in his offspring; and

- Paternal alcohol use leads to decreased newborn birth weight, marked reduction in overall brain size and impaired cognitive function.

"This new field of inherited paternal epigenetics needs to be organized into clinically applicable recommendations and lifestyle alternations," Kitlinska says. "And to really understand the epigenetic influences of a child, we need to study the interplay between maternal and paternal effects, as opposed to considering each in isolation."

###

The study's co-authors are Jonathan Day, MS, Soham Savani, MS, Ben Krempley, MS, and Matthew Nguyen, MS, graduates of Georgetown's Special Masters Program in Physiology.

This study was supported in part by National Institutes of Health grants (1R01CA123211, 1R03CA178809, R01CA197964 and 1R21CA198698).

About Georgetown University Medical Center

Georgetown University Medical Center (GUMC) is an internationally recognized academic medical center with a three-part mission of research, teaching and patient care (through MedStar Health). GUMC's mission is carried out with a strong emphasis on public service and a dedication to the Catholic, Jesuit principle of cura personalis -- or "care of the whole person." The Medical Center includes the School of Medicine and the School of Nursing & Health Studies, both nationally ranked; Georgetown Lombardi Comprehensive Cancer Center, designated as a comprehensive cancer center by the National Cancer Institute; and the Biomedical Graduate Research Organization, which accounts for the majority of externally funded research at GUMC including a Clinical and Translational Science Award (UL1TR001409-01) from the National Institutes of Health.

Georgetown University Medical Center


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