Science Current Events | Science News | Brightsurf.com
 

Large global range of prices for hepatitis C medicines raises concerns about affordability

June 01, 2016

The prices and affordability of recently developed and highly effective direct-acting antivirals for treating hepatitis C (HCV) vary greatly among countries worldwide, according to a study published this week in PLOS Medicine. Suzanne Hill and colleagues from the World Health Organization undertook an economic analysis of prices for a 12-week course of treatment with sofosbuvir and ledipasvir/sofosbuvir in 30 countries - mostly European as well as Egypt and Mongolia, adjusting for average 2015 exchange rates and purchasing power parity (PPP). While the nominal price based on exchange rates was highest in the US (US$72,765 for a 12-week course of ledipasvir/sofosbuvir), PPP-adjusted prices in Central and Eastern European countries were highest, costing up to 1.63 times as much in Poland (PPP$118,754 for a 12 week course of ledipasvir/sofosbuvir). The researchers went on to calculate the cost of treating the entire HCV infected population in each of the countries studied. Using previous estimates of HCV burden by country, they calculated that it would range from 10.5% of the total pharmaceutical expenditure (TPE) to treat all HCV patients in the Netherlands with the new HCV medications, to 190.5% of the TPE to treat all patients in Poland.

The authors note that their analysis is limited by the accuracy of the estimates of the numbers of people infected and price information that was accessible, and that some actual prices may be lower than the publicly accessible numbers because of confidential discounts. They also note, however, that they only considered the cost of sofosbuvir and ledipasvir/sofosbuvir and did not consider extra costs of treatment such as screening and follow-up. The authors say their analysis illustrates the wide range of affordability worldwide and suggests a need for an updated pricing system: "In order for countries to increase investment and minimise the burden of hepatitis C, governments and industry stakeholders will need to jointly develop and implement fairer pricing frameworks that deliver lower and more affordable prices".

In an accompanying Perspective, Elliot Marseille and James G. Kahn discuss the pricing of these new HCV medications in relation to the high initial cost when HIV anti-retroviral therapy was introduced in the 1990s. Marseille and Kahn compare and contrast the situations, and suggest ways forward such as treating a proportion of cases initially, to spread the upfront cost of HCV treatment over several years while fighting for lower drug prices.

###

Research Article

Funding:

The authors received no specific funding for this work.

Competing Interests:

SH is a member of the PLOS Medicine Editorial Board. KTT has been an employee of Deloitte Australia within the past 5 years. Deloitte Australia has provided consulting services to pharmaceutical companies. However, KTT has not been involved in any project directly related to the content of this manuscript that can lead to conflict of interest.

Citation:

Iyengar S, Tay-Teo K, Vogler S, Beyer P, Wiktor S, de Joncheere K, et al. (2016) Prices, Costs, and Affordability of New Medicines for Hepatitis C in 30 Countries: An Economic Analysis. PLoS Med 13(5): e1002032. doi:10.1371/journal.pmed.1002032

Author Affiliations:

World Health Organization, Geneva, Switzerland

WHO Collaborating Centre for Pharmaceutical Pricing and Reimbursement Policies, Health Economics Department, Gesundheit Ă-sterreich, Vienna, Austria

PLOS


Related Hepatitis Current Events and Hepatitis News Articles


Autism care improved, diagnosis time shortened by new MU program
Wait lists for a specialist to confirm an autism diagnosis can be agonizing and last months. As the prevalence of autism and autism spectrum disorders increase, so does the demand for a health care system that is fully equipped to respond to the complex needs associated with autism.

Study reveals protein that dials immune responses up and down
Research led by scientists at the Sanford Burnham Prebys Medical Discovery Institute (SBP) has identified a new regulator of immune responses.

Could hepatitis C treatments help prevent virus transmission?
An international team of researchers has shed light on the potential impact of new drugs for hepatitis C virus (HCV).

Experimental drug against hepatitis C slows down Zika virus infection in mice
Virologists from KU Leuven, Belgium, have shown that an experimental antiviral drug against hepatitis C slows down the development of Zika in mice. The research team was led by Professor Johan Neyts from the Laboratory of Virology and Chemotherapy.

New study finds asthma patients rely heavily on rescue inhalers, difficult to diagnose
In a new national survey of asthma patients, Health Union, and its new online community Asthma.net, reveals that most were satisfied with the care they received; however, the most frequently used form of treatment, at 89%, is the rescue inhaler.

Alcohol accelerates liver damage in people living with hepatitis C
Drinking alcohol can increase the risk of illness and death from the hepatitis C virus. A new national household study of U.S. adults published in the American Journal of Preventive Medicine shows that many people living with hepatitis C report either former or current excessive alcohol use.

Immunization rates climb when pediatricians have easy access to vaccination records
Exchange of immunization data between a centralized city immunization registry and provider electronic health records led to significant improvements in pediatric immunization coverage, a reduction in over-immunization for adolescents, and increased completeness of immunization records.

Studies demonstrate improved safety results achieved with investigational drug for hep B
Studies presented today at The International Liver Congress™ 2016 in Barcelona, Spain, demonstrate that tenofovir alafenamide (TAF) improves patient safety while maintaining efficacy in patients with chronic Hepatitis B virus (HBV) infection compared to tenofovir disoproxil fumarate (Viread, TDF).

New treatment algorithm can predict benefit of treatment in end-stage liver disease
A new algorithm designed to help physician decision-making in End-Stage Liver Disease (ESLD), was able to accurately predict death in 96% of patients with ESLD.

Study demonstrates benefits of existing treatment for hepatitis D patients
New research presented today shows that interferon alpha (IFNa) based therapies are effective in suppressing disease progression in a severe form of chronic viral hepatitis, Hepatitis delta.
More Hepatitis Current Events and Hepatitis News Articles

NOFX: The Hepatitis Bathtub and Other Stories

NOFX: The Hepatitis Bathtub and Other Stories
by NOFX (Author), Jeff Alulis (Author)


NOFX: The Hepatitis Bathtub and Other Stories is the first tell-all autobiography from one of the world's most influential and controversial punk bands. Fans and non-fans alike will be shocked by the stories of murder, suicide, addiction, counterfeiting, riots, bondage, terminal illness, the Yakuza, and drinking pee. Told from the perspective of each of the band's members, this book looks back at more than thirty years of comedy, tragedy, and completely inexplicable success.


HEPATITIS: A-to-E, Autoimmune, & Drug-induced: Symptoms, Transmissions, Diagnosis,  Treatments, Diet, Preventions, Research

HEPATITIS: A-to-E, Autoimmune, & Drug-induced: Symptoms, Transmissions, Diagnosis, Treatments, Diet, Preventions, Research
by James Lee Anderson (Author)


“Although, your health condition may impact your everyday life, do not let it define who you are.” Most people have heard of hepatitis, but few understand the harm posed by this potentially deadly collection of diseases. This text covers what you need to know about the disease. Inside, you’ll be able to know: (1) between acute and chronic hepatitis, (2) the different types of hepatitis, from A to E, (3) symptoms, causes and transmissions, diagnosis, treatments, and preventions, (4) about drug-induced hepatitis, (5) about autoimmune hepatitis, (6) how liver biopsy is done, (7) alternative treatments, (8) how to manage the pain in hepatitis, (9) how to manage mental health, (10) how to manage together diabetes and hepatitis, (11) what the diet and nutrition is for people with...

Hepatitis C: A Complete Guide for Patients and Families (A Johns Hopkins Press Health Book)

Hepatitis C: A Complete Guide for Patients and Families (A Johns Hopkins Press Health Book)
by Paul J. Thuluvath (Author)


The liver is the body’s workhorse. It makes proteins and bile, processes fats, and detoxifies drugs and alcohol. The liver is a resilient organ, but it is susceptible to damage from a number of sources, including viral infections. Such infections cause inflammation of the liver, called hepatitis. This book is a comprehensive guide to hepatitis C, which affects about 3 percent of the world’s population―3 to 4 million people in the United States alone. Some people with acute hepatitis C infection will be cured without any treatment, but when hepatitis C becomes chronic it may cause cirrhosis, liver cancer, and death.Hepatitis C is transmitted from an infected person to an uninfected person by sharing drug-injecting equipment, snorting cocaine, having sex, or getting a blood...

Hepatitis B Treatment: An Essential Self-Help Guide for Treating and Curing Hepatitis B (Hep B)

Hepatitis B Treatment: An Essential Self-Help Guide for Treating and Curing Hepatitis B (Hep B)
by Kandice Holverson (Author)


Hepatitis B is an infectious disease caused by a virus that attacks the DNA of your body's cells. It can occur without symptoms in some individuals until the infection becomes life threatening. For this reason, early detection and early action are crucial so as to prevent further complications and begin treatment measures. However, finding a cure for Hepatitis B virus can be a challenging task because people respond differently to medication. Since there is no single treatment for the condition and viruses are difficult to destroy, it is important to get a proper diagnosis from your doctor and commence treatment immediately after. Delaying this process can worsen the condition. This book is designed to help you become aware of the various treatment options for Hepatitis B. It will also...

Healing Hepatitis and Liver Disease Naturally: Detoxification. Liver gall bladder flush & Cleanse. Cure Hepatitis C and Hepatitis B. Lower blood cholesterol and stop cirrhosis

Healing Hepatitis and Liver Disease Naturally: Detoxification. Liver gall bladder flush & Cleanse. Cure Hepatitis C and Hepatitis B. Lower blood cholesterol and stop cirrhosis
by Peter Oyakhire (Author)


LIVE YOUR LIFE EXPECTANCY WITH CHRONIC LIVER DISEASE.

Studies show that all wellness traditions except western medicine offer detoxification and toxic waste management as a means of natural healing. Using the principles of natural healing and detoxification, Dr. Alexis Carrel, a Nobel Prize winner kept chicken heart alive for 38 years. He believed that cells could live indefinitely and that the secret of life is to feed nutrients to cells and to saturate the cells with Oxygen. If you can't get nutrients into the cells and you don't remove the toxins, the cells will be poisoned by their own waste products. He had found the secret to ageless body and timeless health.

Often overlooked is the pain associated with orthodox management of infective and degenerative liver diseases...

Get Hepatitis C Medication From India: Ultimate Guide to Saving Over 90% On the Cost of Hepatitis C Treatments

Get Hepatitis C Medication From India: Ultimate Guide to Saving Over 90% On the Cost of Hepatitis C Treatments


Original Hepatitis C treatments can range upwards of $100,000 or more for patients. However, generic drug medications that provide the same benefits exist at significantly low prices in India. Due to the extreme cost of treatments in the United States, many patients travel to India to purchase the mediciations or even order the generic drugs online, all while following the legal formalities.This book discusses a 5-step procedure to obtain a low-cost treatment for Hepatitis C.

Viral Hepatitis

Viral Hepatitis
by Howard C. Thomas (Editor), Anna S. F. Lok (Editor), Stephen A. Locarnini (Editor), Arie J. Zuckerman (Editor)


The 4th edition of Viral Hepatitis covers comprehensively the entire complex field of infections caused by all of the different hepatitis viruses, which affect many millions of people throughout the world with considerable morbidity and mortality. Howard Thomas and Arie Zuckerman are joined by Anna Lok from the USA and Stephen Locarnini from Australia as Editors.  They have recruited leading researchers and physicians from many countries, who have produced an authoritative account of current knowledge and research on this important infection, including new insights into immune response to HBV and HCV.  The result is a comprehensive account on all aspects of viral hepatitis, including rapid advances in the diagnosis, management, treatment and prevention of a complex infection, which in...

Herbs for Hepatitis C and the Liver (A Storey Medicinal Herb Guide)

Herbs for Hepatitis C and the Liver (A Storey Medicinal Herb Guide)
by Stephen Harrod Buhner (Author)


Providing practical guidance and hope, Stephen Harrod Buhner offers a thorough examination of the most effective herbal remedies for hepatitis C. While promoting a protocol of cleansing the liver and strengthening the immune system through a combination of diet, herbal medicines, and lifestyle changes, this guide will help you choose the best remedies for your individual needs. Clear descriptions of how common herbal treatments work to combat hepatitis C will empower you to make informed choices that can successfully mitigate your suffering. 

Hepatitis C Treatment: Spot The Symptoms Early And Get Rid Of Hepatitis C Forever (Hepatitis C Transmission, Hepatitis C Cure, Hepatitis C Symptoms , Preventing Hepatitis C)

Hepatitis C Treatment: Spot The Symptoms Early And Get Rid Of Hepatitis C Forever (Hepatitis C Transmission, Hepatitis C Cure, Hepatitis C Symptoms , Preventing Hepatitis C)


Hepatitis C Treatment
Spot The Symptoms Early And Get Rid Of Hepatitis C Forever !
Free Bonus Included - Get It At The End Of The Book!

You’re about to discover how to spot the symptoms of Hepatitis C and get the necessary treatment.
The majority of those with Hepatitis C are not usually aware of their condition. By the time they discover, it's usually late. This makes it difficult to successfully get rid of this disease. In this book, you will learn about the symptoms to look out for, types of treatments available and more useful information about Hepatitis C.

Hepatitis C is an infectious disease that is caused by the hepatitis C virus (HCV). The word hepatitis means inflammation of the liver. Being the second most important organ in the body, an...

The First Year---Hepatitis B: An Essential Guide for the Newly Diagnosed

The First Year---Hepatitis B: An Essential Guide for the Newly Diagnosed
by William Finley Green (Author), Hari Conjeevaram (Foreword)


The hepatitis B virus causes an estimated one million deaths each year worldwide, and despite the availability of a hepatitis B vaccine, a combined lack of awareness and educational resources has turned this virus into a deadly epidemic. Author William Finley Green, who has lived with hepatitis B for almost twenty-five years and has become an expert on the condition, guides those newly diagnosed step-by-step through the first year following diagnosis. He provides charts and tables, crucial information about the nature of the disease, treatment options, diet, exercise, social concerns, the myriad of emotional issues that accompany the diagnosis, and much more. The First Year™—Hepatitis B will be an invaluable guide for everyone struggling to come to terms with their hepatitis B...

© 2017 BrightSurf.com