Science Current Events | Science News |

Newly discovered gene regulates hyperglycemia-induced beta cell death in type 2 diabetes

June 01, 2016

It's no secret that over time, elevated levels of blood glucose (hyperglycemia) can induce the death of the pancreatic beta cells. The death of these cells, which are responsible for the production of insulin, underlies much of the pathology of diabetes. Exactly how and why they die is not fully understood, but a new research report published online in The FASEB Journal by a team of Korean scientists, suggests that a protein called, "TSPAN2" may play a key role hyperglycemia-induced beta cell death and might serve as a new therapeutic target.

"The prevalence of Type 2 diabetes is significantly increased nowadays," said Ik-Soon Jang, Ph.D., study author and senior scientist in the Division of Bioconvergence at the Korea Basic Science Institute in Seoul, South Korea. "Our study will be potentially helpful to develop the medicine for the treatment of type 2 diabetes."

To make this discovery, scientists grew human pancreatic beta cells in culture and analyzed their gene expression patterns. They found that the highly expressed genes and proteins under hyperglycemic conditions can regulate cell death through various cell signals, but in general, the primary mechanisms of β-cell apoptosis includes signaling through FAS ligand and various pro-inflammatory cytokines.

"The revelation of a novel pathway related to the induction of pancreatic beta cells apoptosis could have exciting implications for future treatments for Type 2 diabetes," said Thoru Pederson, Ph.D., Editor-in-Chief of The FASEB Journal. "If drugs that inhibit the loss of these cells can be developed, it may be possible to attenuate disease progression."


Submit to The FASEB Journal by visiting, and receive monthly highlights by signing up at The FASEB Journal is published by the Federation of the American Societies for Experimental Biology (FASEB). It is the world's most cited biology journal according to the Institute for Scientific Information and has been recognized by the Special Libraries Association as one of the top 100 most influential biomedical journals of the past century.

FASEB is composed of 30 societies with more than 125,000 members, making it the largest coalition of biomedical research associations in the United States. Our mission is to advance health and welfare by promoting progress and education in biological and biomedical sciences through service to our member societies and collaborative advocacy.

Details: In-Hu Hwang, Junsoo Park, Jung Min Kim, Seung Il Kim, Jong-Soon Choi, Kyung-Bok Lee, Sung Ho Yun, Min-Goo Lee, Soo Jung Park, and Ik-Soon Jang. Tetraspanin-2 promotes glucotoxic apoptosis by regulating the JNK/β-catenin signaling pathway in human pancreatic β cells. DOI: 10.1096/fj.201600240RR ;

Federation of American Societies for Experimental Biology

Related Pancreatic Beta Cells Current Events and Pancreatic Beta Cells News Articles

Stem cells from diabetic patients coaxed to become insulin-secreting cells
Signaling a potential new approach to treating diabetes, researchers at Washington University School of Medicine in St. Louis and Harvard University have produced insulin-secreting cells from stem cells derived from patients with type 1 diabetes.

New procedure could improve success rate of cell transplant to cure type 1 diabetes
New research suggests pretreating cells with a peptide hormone may improve the success rate of pancreatic islet cell transplants, a procedure that holds great promise for curing Type 1 diabetes.

U-M researchers find noninvasive way to view insulin in pancreas
Scientists and doctors have wanted to know how much insulin a person has in their body, but haven't been able to know the exact amount without the patient being deceased and actually removing the pancreas," says Peter Arvan, division chief of Metabolism, Endocrinology & Diabetes at the University of Michigan.

Scientists discover molecular link between psychiatric disorders and type 2 diabetes
There may be a genetic connection between some mental health disorders and type 2 diabetes. In a new report appearing in the February 2016 issue of The FASEB Journal, scientists show that a gene called "DISC1," which is believed to play a role in mental health disorders, such as schizophrenia, bipolar disorder and some forms of depression, influences the function of pancreatic beta cells which produce insulin to maintain normal blood glucose levels.

Insulin-producing pancreatic cells created from human skin cells
Scientists at the Gladstone Institutes and the University of California, San Francisco (UCSF) have successfully converted human skin cells into fully-functional pancreatic cells.

TSRI team finds unique anti-diabetes compound using powerful new drug-discovery method
Scientists from The Scripps Research Institute (TSRI) have deployed a powerful new drug discovery technique to identify an anti-diabetes compound with a novel mechanism of action.

Microtubules act as cellular 'rheostat' to control insulin secretion
Microtubules -- cellular "highways" that deliver cargo to the cell membrane for secretion -- have a surprising role in pancreatic beta cells. Instead of facilitating glucose-stimulated insulin secretion, they limit it, a team of Vanderbilt investigators reported recently in Developmental Cell.

Rescuing intestinal stem cells from attack in type 1 diabetes
Up to 80 percent of people with long-standing type 1 diabetes develop gastrointestinal symptoms--abdominal pain, bloating, nausea, vomiting, diarrhea, constipation and fecal incontinence--that severely diminish quality of life.

Scientists report success using zebrafish embryos to identify potential new diabetes drugs
In experiments with 500,000 genetically engineered zebrafish embryos, Johns Hopkins scientists report they have developed a potentially better and more accurate way to screen for useful drugs, and they have used it to identify 24 drug candidates that increase the number of insulin-producing cells in the pancreas.

An imbalance of cellular bioenergetics in pancreatic beta-cells links to type 2 diabetes
Impaired activation of mitochondrial energy metabolism in the presence of glucose has been demonstrated in pancreatic beta-cells from patients with type 2 diabetes.
More Pancreatic Beta Cells Current Events and Pancreatic Beta Cells News Articles

The Pancreatic Beta Cell, Volume 95 (Vitamins and Hormones)

The Pancreatic Beta Cell, Volume 95 (Vitamins and Hormones)
by Gerald Litwack (Series Editor)

First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. The Series provides up-to-date information on vitamin and hormone research spanning data from molecular biology to the clinic. A volume can focus on a single molecule or on a disease that is related to vitamins or hormones.  A hormone is interpreted broadly so that related substances, such as transmitters, cytokines, growth factors and others can be reviewed. This volume focuses on the pancreatic beta cell.Expertise of the contributorsCoverage of a vast array of subjectsIn depth current information at the molecular to the clinical levelsThree-dimensional structures in colorElaborate signaling pathways

Pancreatic Beta Cell in Health and Disease

Pancreatic Beta Cell in Health and Disease
by Susumu Seino (Editor), Graeme I. Bell (Editor)

The beta cells of the pancreatic islets of Langerhans are the only cells in the body that produce and secrete insulin. This metabolic hormone plays a central role in the maintenance of glucose homeostasis. This book provides a comprehensive review of the beta cell in health and disease. The book’s primary aim is to encourage investigators to become actively involved in diabetes research and the search for new approaches to prevent and treat diabetes.

Control of Pancreatic Beta Cell Function and Plasticity in Health and Diabetes (Current and Future Developments in Physiology Book 1)

Control of Pancreatic Beta Cell Function and Plasticity in Health and Diabetes (Current and Future Developments in Physiology Book 1)
by Bentham Science Publishers

Plasticity in insulin-producing cells (β-cells) of the pancreas is a major contributor to metabolic control. Targeted regeneration of pancreatic β-cells for the reversal of diabetes (by optimizing β-cells mass and proliferation to meet metabolic requirements and counter autoimmune response) is still a theoretical intervention. This monograph reviews the biology, ontogeny, capabilities, and present practical limitations of β-cell plasticity. Relevant biochemical pathways are described with the inclusion of information about how they change with aging, during pregnancy, and with diet. Readers will learn the following key aspects about β-cell plasticity:
-current knowledge of pancreatic β-cells development, and how β-cell mass and proliferation change throughout the human...

Islet Transplantation and Beta Cell Replacement Therapy

Islet Transplantation and Beta Cell Replacement Therapy
by A. M. James Shapiro (Editor), James A. M. Shaw (Editor)

Beta cell replacement through transplantation remains the only treatment option for Type 1 diabetes enabling restoration of near-physiological glucose levels without significant hypoglycemia. Outlining the most recent advances and research breakthroughs, this practical guide and reference work explores the impact of islet cell transplantation and brings together leading multidisciplinary proponents critical to future success in the field. Edited by a surgeon and an endocrinologist at the forefront of the technology, this volume considers challenges associated with this procedure including lack of sufficient donor organs and the side effects of immunosuppressive therapy, as well as the potential benefits for current and future patients.

Islet Transplantation and Beta Cell...

Pancreatic Beta Cell in Health and Disease (2007-12-19)

Pancreatic Beta Cell in Health and Disease (2007-12-19)
by Springer (Publisher)

Pancreatic Beta Cell in Health & Disease. (Springer,2010) [Paperback]

Pancreatic Beta Cell in Health & Disease. (Springer,2010) [Paperback]
by Springer,2010 (Publisher)

Pancreatic Beta Cell in Health & Disease. . Springer, 2010 .

Chapter 006, Autophagy in the Homeostasis of Pancreatic β-Cells

Chapter 006, Autophagy in the Homeostasis of Pancreatic β-Cells
by Academic Press

NOTE: This is a single chapter excerpted from the book Autophagy in Health and Disease, made available for individual purchase. Additional chapters, as well as the entire book, may be purchased separately.
Autophagy in Health and Disease offers an overview of the latest research in autophagy with a translational emphasis. This publication takes scientific research in autophagy a step further and offers integrated content with advancements in autophagy from cell biology and biochemical research to clinical treatments. A necessary reference for the bookshelf of medical and scientific researchers and students, Autophagy in Health and Disease presents high quality, reputable information on autophagy, allowing the reader quick access to the most applicable information.

Pancreatic Beta Cell in Health and Disease 1st edition by Seino, Susumu published by Springer Hardcover

Pancreatic Beta Cell in Health and Disease 1st edition by Seino, Susumu published by Springer Hardcover
by Springer (Publisher)

The Pancreatic Beta Cell, Volume 95 (Vitamins and Hormones) (2014-03-14)

The Pancreatic Beta Cell, Volume 95 (Vitamins and Hormones) (2014-03-14)
by unknown (Author)

Pancreatic Beta Cell in Health and Disease by Susumu Seine (2007-12-18)

Pancreatic Beta Cell in Health and Disease by Susumu Seine (2007-12-18)
by Susumu Seine (Author)

© 2017