Science Current Events | Science News | Brightsurf.com
 

Ancient anti-inflammatory drug salicylic acid has cancer-fighting properties

June 01, 2016


Scientists from the Gladstone Institutes have identified a new pathway by which salicylic acid--a key compound in the nonsteroidal anti-inflammatory drugs aspirin and diflunisal--stops inflammation and cancer.

In a study published in eLife, the researchers found that both salicylic acid and diflunisal suppress two key proteins that help control gene expression throughout the body. These sister proteins, p300 and CREB-binding protein (CBP), are epigenetic regulators that control the levels of proteins that cause inflammation or are involved in cell growth. By inhibiting p300 and CBP, salicylic acid and diflunisal block the activation of these proteins and prevent cellular damage caused by inflammation. This study provides the first concrete demonstration that both p300 and CBP can be targeted by drugs and may have important clinical implications.

"Salicylic acid is one of the oldest drugs on the planet, dating back to the Egyptians and the Greeks, but we're still discovering new things about it," said senior author Eric Verdin, MD, associate director of the Gladstone Institute of Virology and Immunology. "Uncovering this pathway of inflammation that salicylic acid acts upon opens up a host of new clinical possibilities for these drugs."

Earlier research conducted in the laboratory of co-author Stephen D. Nimer, MD, director of Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine, and a collaborator of Verdin's, established a link between p300 and the leukemia-promoting protein AML1-ETO. In the current study, scientists at Gladstone and Sylvester worked together to test whether suppressing p300 with diflunisal would suppress leukemia growth in mice. As predicted, diflunisal stopped cancer progression and shrunk the tumors in the mouse model of leukemia.

"The ability to repurpose drugs that are already FDA-approved to be part of novel therapies for cancer patients is incredibly exciting," said Nimer. "We have conducted a clinical trial of salicylic acid in patients with hematologic cancers and found it to be safe. Thus, this collaborative effort to develop novel epigenetic therapies is an important next step in our journey to find more effective treatment for leukemia patients."

The scientists are now pursuing a clinical trial that will test the ability of salicylic acid to treat patients with leukemia as part of novel combination therapies. Other possible clinical applications for salicylic acid include other forms of cancer, type 2 diabetes, inflammatory diseases, and even neurodegenerative disorders, such as Alzheimer's disease. Prior Gladstone research showed that another drug containing salicylic acid prevented the accumulation of tau in neurons and protected against cognitive decline in a mouse model of dementia.

###

Other Gladstone scientists on the studies include first author Kotaro Shirakawa, Hyung Lim, Intelly Lee, Tadahiro Shimazu, John Newman, Sebastian Schroder, and Melanie Ott. Researchers from the University of Miami, University of Pennsylvania, and the National Cancer Institute also took part in the study.

About the Gladstone Institutes

To ensure our work does the greatest good, the Gladstone Institutes focuses on conditions with profound medical, economic, and social impact--unsolved diseases of the brain, the heart, and the immune system. Affiliated with the University of California, San Francisco, Gladstone is an independent, nonprofit life science research organization that uses visionary science and technology to overcome disease.


Gladstone Institutes


Related Salicylic Acid Current Events and Salicylic Acid News Articles


Aspirin targets key protein in neurodegenerative diseases
A new study finds that a component of aspirin binds to an enzyme called GAPDH, which is believed to play a major role in neurodegenerative diseases, including Alzheimer's, Parkinson's and Huntington's diseases.

New study provides key insights into aspirin's disease-fighting abilities
Researchers have found that salicylic acid targets the activities of HMGB1, an inflammatory protein associated with a wide variety of diseases, offering hope that more powerful aspirin-like drugs may be developed.

Ionic and covalent drug delivery
The human organism is composed of numerous types of molecules, both simple and complex, and all fundamental processes in a living body occur in water solutions.

Dual internal clocks keep plant defenses on schedule
Time management isn't just important for busy people -- it's critical for plants, too. A Duke University study shows how two biological clocks work together to help plants deal with intermittent demands such as fungal infections, while maintaining an already-packed daily schedule of activities like growth.

Bloom preservation
If you want your cut gerberas to last longer in the vase, you could try a flower food made from acids and urea.

New computer model predicts gut metabolites to better understand gastrointestinal disease
Tufts University School of Engineering researchers and collaborators from Texas A&M University have published the first research to use computational modeling to predict and identify the metabolic products of gastrointestinal (GI) tract microorganisms.

Drug-food interactions in mountaineering
UPV/EHU-University of the Basque Country researchers have studied the nutritional and health situations existing at high altitudes as well as the routinely used nutritional ergogenic and pharmacological aids.

Ants Protect Acacia Plants Against Pathogens
The biological term "symbiosis" refers to what economists and politicians usually call a win-win situation: a relationship between two partners which is beneficial to both.

Microbes help beetles defeat plant defenses
Some symbiotic bacteria living inside Colorado potato beetles can trick plants into reacting to a microbial attack rather than that of a chewing herbivore, according to a team of Penn State researchers who found that the beetles with bacteria were healthier and grew better.

Handheld device for detecting counterfeit and substandard medicines tested by PQM
With substandard and counterfeit medicines a dangerous and growing problem in the developing world and elsewhere, identifying new technologies to detect such drugs is an urgent matter.
More Salicylic Acid Current Events and Salicylic Acid News Articles

Salicylic acid induced amelioration of salinity stress in mungbean

Salicylic acid induced amelioration of salinity stress in mungbean
by Pooja Dhansu (Author), Kamal Dutt Sharma (Author)


Salinity stress decreased the growth of mungbean in terms of plant height, dry matter accumulation and leaf area. However, treatment with SA increased the growth parameters under salinity stress. Application of SA improved the plant water status irrespective of salinity levels. Higher concentration of SA was more effective to brought consecutive improvement in gaseous exchange under salinity. Membrane injury and lipid peroxidation enhanced under salinity stress but salicylic acid application increased the membrane stability and decreased MDA production. Biochemical metabolites i.e. chlorophyll and protein content declined under salinity stress. Exogenous SA application increased free proline, total soluble carbohydrates and free amino acids under salinity. The ionic composition i.e. Na+,...

Salicylic Acid and Jasmonic Acid: Biosynthesis, Functions and Role in Plant Development (Plant Science Research and Practices)

Salicylic Acid and Jasmonic Acid: Biosynthesis, Functions and Role in Plant Development (Plant Science Research and Practices)
by Phyllis Santos (Editor)




The World Market for Salicylic Acid and Its Salts and Esters: A 2018 Global Trade Perspective

The World Market for Salicylic Acid and Its Salts and Esters: A 2018 Global Trade Perspective
by Icon Group International (Author)


This series was created for international firms who rely on foreign markets for a substantial portion of their business or who might be threatened by international competition. The estimates given in this report were created using a methodology developed by and implemented under the direct supervision of Professor Philip M. Parker, the INSEAD Chair Professor of Management Science. The methodology relies on historical figures across countries. The figures should be seen as market estimates, as opposed to historical records, as these are projected for a specific year of trade.

SALICYLIC ACID: Plant Growth and Development

SALICYLIC ACID: Plant Growth and Development
by Shamsul Hayat (Editor), Aqil Ahmad (Editor), Mohammed Nasser Alyemeni (Editor)


The book “Salicylic acid: A Plant Hormone” was first published in 1997 and was praised for its excellent balance of traditional and modern topics. This time, we're building on the success of the prior edition to provide an even more effective second edition. The present book is comprised of 16 chapters highlighting the updated mechanisms of its biosynthesis, physiological role, its action in response to water deficit, relationship of SA with signal transduction, transport of SA and related compounds. Further, the interplay between environmental signals and SA, its impact on transport and distribution of sugars, salicylic acid mediated stress-induced flowering and some aspects of interplay of SA with JA during the establishment of plant resistance to pathogens with different types of...

SALICYLIC ACID - A Plant Hormone

SALICYLIC ACID - A Plant Hormone
by Shamsul Hayat (Editor), Aqil Ahmad (Editor)


Phytohormones are closely involved in directing plant growth, coordinating with the metabolism that provides energy and the building blocks to develop the form that we recognize as plant. This book provides information on Salicylic Acid, a chemical that has significant impact on plant life, and could be raised to the status of the phytohormones because of its significant impact on various aspects of the plant life.

Salicylic Acid and Nutrient Regulation: Sustainable Productivity

Salicylic Acid and Nutrient Regulation: Sustainable Productivity
by Pramod Singh (Editor)


The book is insight for the mechanism of higher plant productivity under adverse environmental conditions. plant growth and productivity under nutrient stress condition is regulated by endogenous metabolites like SA and other signaling molecules. Present book is useful for Science students,Ph D Scholar and researchers to develop the concepts and techniques for higher plant productivity without the utilization of chemical fertilizers.

Salicylic Acid and Environmental Stress

Salicylic Acid and Environmental Stress
by Mohd Mazid (Author), Taqi Ahmed Khan (Author), Firoz Mohammad (Author)


Salicylic acid is true plant hormones that induces defence reaction in plant immunity and protrude responses to biotic and abiotic stress tolerance. The identification of the unresolved signaling targets and molecular modes responsible for inducing resistance to tolerance the harmful effects of biotic and abiotic stresses could satisfy the researchers to understand the complex Salicylic Acid signaling behaviour.

Salicylic acid effect on maize grown in saline area: Effect of Salicylic acid on Physiological Characterization of Maize grown in Saline area of Charsada district

Salicylic acid effect on maize grown in saline area: Effect of Salicylic acid on Physiological Characterization of Maize grown in Saline area of Charsada district
by Shah Fahad (Author), Asghari Bano (Author), Shah Saud (Author)


In the name of Allah, the most gracious, the most merciful, the one and the only, the creator, who is perfect in all characteristics, worthy of worship, only source of knowledge and wisdom to all humanity. I owe my deepest respect to the Holy Prophet Hazrat Muhammad (PBUH), the city of knowledge, who guided the mankind from darkness of ignorance to the light of awareness. I wish to express my warmest, sincerest thanks and profound gratitude to my supervisor, Professor Dr. Asghari Bano, Department of Plant Sciences, Quaid-i-Azam University, Islamabad, for her affectionate efforts, sympathetic attitude, kind guidance, support and encouragement. I also pay my thanks and regards to Professor Dr. Mir Ajab Khan Chairman, Department of Plant Science Quaid-i-Azam University, Islamabad, for...

Salicylic Acid Induced changes in Pea Seed Development and Germination: Salicylic Acid Induced changes during Seed Development and Germination of Pea (Pisum sativum L.)

Salicylic Acid Induced changes in Pea Seed Development and Germination: Salicylic Acid Induced changes during Seed Development and Germination of Pea (Pisum sativum L.)
by Ghulam Murtaza (Author), Rehana Asghar (Author)


The phytohormone salicylic acid is found in plants with roles in photosynthesis, transpiration, ion uptake, transport, plant growth and development. It is involved in cell signaling, mediating in plant defense against pathogens. Because of the economic importance, the seed metabolism epecially the accumulation of storage products, became a subject of intensive investigation. The book offers comprehensive understanding of the bochemical changes induced by salicylic acid during seed development and germination of pea (Pisum sativum L.). The book focuses on the changes in Ascorbate peroxidase, acid phosphatase, a-amylase, sucrose synthase and protein contents during the seed development and grmination in pea. In additon to these biochemical studies, the yield and yield components has also...

Salicylic acid biosynthetic genes expressed in Rhizobium: Rhizobium strains harboring salicylic acid gene via horizontal gene transfer

Salicylic acid biosynthetic genes expressed in Rhizobium: Rhizobium strains harboring salicylic acid gene via horizontal gene transfer
by Ahmed Ibrahim (Author)


It is evident that it is possible to select rhizobial strains harboring recombinant genomes that were efficient in secrete IAA as a plant hormone, as well as, salicylic acid as a inhibitor agent against pathogenic microorganisms. Bacteriocins produced from these recombinant strains had a good performance to inhibit the growth of Agr1513 as an soil pathogen. In addition, rhizobial recombinants appeared symbiotic effectiveness leading to increase grain yield, as well as, improving biochemical traits such as grain protein contents and leaves chlorophyll concentration.

© 2017 BrightSurf.com